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diffuse into tissue and damage cellular structures under skin without immediately apparent damage to skin surface Exposure to a toxic substance that is insufficient to cause a chemical burn can still be very serious, and the lack of a noticeable effect from a chemical exposure is not an indication of safety, particularly in the case of chronic ...
Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. [1] Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell (cytotoxicity) or an organ such as the liver (hepatotoxicity).
An example is through the nicotinic acetylcholine receptor (nAchRs), which is a receptor commonly found along the surfaces of the cells that respond to nicotine stimulation, turning them on or off. Aβ was found manipulating the level of nicotine in the brain along with the MAP kinase , another signaling receptor, to cause cell death.
Aftermath of the 2020 Beirut explosion.. The most dangerous chemical accident recorded in history was the 1984 Bhopal gas tragedy in India, in which more than 3,000 people died after highly toxic methyl isocyanate was released at a Union Carbide pesticides factory.
Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval.
Oxidative stress mechanisms in tissue injury. Free radical toxicity induced by xenobiotics and the subsequent detoxification by cellular enzymes (termination).. Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. [1]
ROS can cause cellular damage in a multitude of ways, a few of which being DNA and mitochondrial damage and depletion of antioxidant enzymes such as glutathione. In terms of drug-drug interactions, acetaminophen activates CAR , a nuclear receptor involved in the production of metabolic enzymes, which increases the metabolism of other drugs.
Clostridial toxins have the ability to damage or alter the cell membrane damaging the extracellular matrix of the organism. Toxin A and toxin B are two toxins produced by Clostridioides difficile . Toxin A and toxin B are glycosyltransferases that cause the antibiotic-associated pseudomembranous colitis and severe diarrhea that characterize ...