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Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity, such as from a spinal cord injury or multiple sclerosis. [ 8 ] [ 9 ] It may also be used for hiccups and muscle spasms near the end of life, [ 9 ] and off-label to treat alcohol use disorder [ 10 ] [ 11 ] or opioid withdrawal symptoms. [ 12 ]
Baclofen also inhibits neural function presynaptically, by reducing calcium ion influx, and thereby reducing the release of excitatory neurotransmitters in both the brain and spinal cord. It may also reduce pain in patients by inhibiting the release of substance P in the spinal cord, as well. [5] [25]
Consumers often pay way more for products than what it costs to make. The price may increase if the item is in high demand or is difficult to make. 17 expensive products that cost companies very ...
In 2008, Ameisen wrote a best-selling book, The End Of My Addiction, published in France as Le Dernier Verre (The Last Glass), describing his experience of curing his alcoholism with baclofen. [6] In 2007, an Italian team also showed the effectiveness and the safety of baclofen as a treatment for alcohol addiction. [7]
Doesn't do a thing to make them lay off the coke or meth, though, and hardcore users may use it at high dosages on a daily basis! Aadieu 08:59, 27 April 2010 (UTC) (outdent) The study for alcoholics was only 30 days long; baclofen was administered 12 - 24 hours after the last drink to alcohol dependent individuals or placebo.
Often reserved for spastic cerebral palsy, baclofen can be administered through an intrathecal pump implanted just below the skin of the abdomen or behind the chest wall, with a catheter connected directly to the base of the spine. Intrathecal baclofen pumps sometimes carry serious clinical risks, such as infection or a possibly fatal sudden ...
MGM paid more than $2.7 million to make "The Wizard of Oz" in 1939 — its most expensive production at the time. And that was more than a decade before the average cost for a feature film topped ...
Intrathecal pumps require maintenance and need to be periodically refilled. How frequently this occurs is dependent on several factors, including drug concentration and dosage, and pump size. The refill frequency can range between one and six months for baclofen pumps. [2]
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