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Like Δ 9-THC, 11-hydroxy-THC is a partial agonist at the cannabinoid receptor CB 1, but with significantly higher binding affinity (K i = 0.37 nM compared to Δ 9-THC K i = 35 nM). [7] With respect to cAMP inhibition at CB 1 it displays a similar efficacy to that of Δ 9 -THC (EC 50 = 11 nM vs. EC 50 = 5.2 nM, respectively), but a lower ...
11-Hydroxy-Δ-8-tetrahydrocannabinol (11-OH-Δ 8-THC, alternatively numbered as 7-OH-Δ 6-THC) is an active metabolite of Δ 8-THC, a psychoactive cannabinoid found in small amounts in cannabis. It is an isomer of 11-OH-Δ 9-THC, and is produced via the same metabolic pathway. It was the first cannabinoid metabolite discovered in 1970.
In a pathway that parallels the metabolism of the THC family of cannabinoids, following ingestion HHC undergoes hepatic metabolism by cytochrome p450 (predominantly the CYP3A4 isozyme, with some contribution from CYP2C9 and CYP2C19) to a multitude of oxygenated derivatives, including 8-OH-HHC and 11-OH-HHC. C11-oxidation is the major pathway of ...
The principal active metabolite of THC is 11-hydroxy-THC (11-OH-THC), which is formed by CYP2C9 and is psychoactive similarly to THC. [31] [22] [21] This metabolite is further oxidized to 11-nor-9-carboxy-THC (THC-COOH). In animals, more than 100 metabolites of THC could be identified, but 11-OH-THC and THC-COOH are the predominant metabolites ...
11-Hydroxycannabinol (11-OH-CBN) is the main active metabolite of cannabinol (CBN), one of the active components of cannabis, [1] and has also been isolated from cannabis itself. [2] It is more potent than CBN itself, acting as an agonist of CB 1 with around the same potency as THC , but is a weak antagonist at CB 2 .
More than 11% of high school seniors said in a national survey that they had used delta-8 THC, a psychoactive compound that is derived from hemp, in the last year.
Δ-11-Tetrahydrocannabinol (Delta-11-THC, Δ 11-THC, Δ 9(11)-THC, exo-Tetrahydrocannabinol) is a rare isomer of tetrahydrocannabinol, developed in the 1970s. It can be synthesised from Δ 8 -THC by several different routes, [ 1 ] [ 2 ] [ 3 ] though only the (6aR, 10aR) enantiomer is known.
Behold: 11 THC seltzer options, available in states where cannabis is legal. For specific locations, make sure to check each website’s store locator. Prices and availability are subject to change.