Search results
Results from the WOW.Com Content Network
Notch-mediated juxtacrine signal between adjacent cells Notch signaling steps. The Notch signaling pathway is a highly conserved cell signaling system present in most animals. [1] Mammals possess four different notch receptors, referred to as NOTCH1, NOTCH2, NOTCH3, and NOTCH4. [2] The notch receptor is a single-pass transmembrane receptor protein.
4854 18131 Ensembl ENSG00000074181 ENSMUSG00000038146 UniProt Q9UM47 Q61982 RefSeq (mRNA) NM_000435 NM_008716 RefSeq (protein) NP_000426 NP_032742 Location (UCSC) Chr 19: 15.16 – 15.2 Mb Chr 17: 32.34 – 32.39 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Neurogenic locus notch homolog protein 3 (Notch 3) is a protein that in humans is encoded by the NOTCH3 gene. Function This ...
JAG1 was first identified as a ligand that was able to activate notch receptors when the rat gene Jagged encoding a protein homolog was cloned in 1995. [5] [6] The structure of the JAG1 protein includes a small intracellular component, a transmembrane motif, proceeded by an extracellular region containing a cystine-rich region, 16 EGF-like repeats, a DSL domain, and finally a signal peptide ...
Notch proteins are a family of type 1 transmembrane proteins that form a core component of the Notch signaling pathway, which is highly conserved in animals. The Notch extracellular domain mediates interactions with DSL family ligands , allowing it to participate in juxtacrine signaling .
4851 18128 Ensembl ENSG00000148400 ENSMUSG00000026923 UniProt P46531 Q01705 RefSeq (mRNA) NM_017617 NM_008714 RefSeq (protein) NP_060087 NP_032740 Location (UCSC) Chr 9: 136.49 – 136.55 Mb Chr 2: 26.35 – 26.41 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Neurogenic locus notch homolog protein 1 (Notch 1) is a protein encoded in humans by the NOTCH1 gene. Notch 1 is a single ...
SOX-9 is a target of the Notch signaling pathway, as well as the Hedgehog pathway, [14] and plays a role in the regulation of neural stem cell fate. In vivo and in vitro studies show that SOX-9 negatively regulates neurogenesis and positively regulates gliogenesis and stem cell survival. [15]
3714 16450 Ensembl ENSG00000184916 ENSMUSG00000002799 UniProt Q9Y219 Q9QYE5 RefSeq (mRNA) NM_002226 NM_145159 NM_010588 RefSeq (protein) NP_002217 NP_660142 NP_034718 Location (UCSC) Chr 14: 105.14 – 105.17 Mb Chr 12: 112.87 – 112.89 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Jagged-2 is a protein that in humans is encoded by the JAG2 gene. Function The Notch signaling ...
Numb acts as an oncogene suppressor, inhibiting tumor cell proliferation through suppression of Notch signaling. Increased Notch signaling is observed in tumors where Numb activity has been lost and retrovirally mediated transient overexpression of Numb protein in these tumors restored basal levels of Notch signaling and significantly reduced ...