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Old School RuneScape is a massively multiplayer online role-playing game (MMORPG), developed and published by Jagex.The game was released on 16 February 2013. When Old School RuneScape launched, it began as an August 2007 version of the game RuneScape, which was highly popular prior to the launch of RuneScape 3.
I think RuneScape is a game that would be adopted in the English-speaking Indian world and the local-speaking Indian world. We're looking at all those markets individually." [78] RuneScape later launched in India through the gaming portal Zapak on 8 October 2009, [79] and in France and Germany through Bigpoint Games on 27 May 2010. [80]
5743 19225 Ensembl ENSG00000073756 ENSMUSG00000032487 UniProt P35354 Q05769 RefSeq (mRNA) NM_000963 NM_011198 RefSeq (protein) NP_000954 NP_035328 Location (UCSC) Chr 1: 186.67 – 186.68 Mb Chr 1: 149.98 – 149.98 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclooxygenase-2 (COX-2), also known as prostaglandin-endoperoxide synthase 2 (HUGO PTGS2), is an enzyme that in humans is ...
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The inhibition of COX-2 is paramount for the anti-inflammatory and analgesic function of the selective COX-2 inhibitor celecoxib. However, with regard to this drug's promise for the therapy of advanced cancers, it is unclear whether the inhibition of COX-2 plays a dominant role, and this has become a controversial and intensely researched issue.
COX is a common target for anti-inflammatory drugs. The most significant difference between the isoenzymes, which allows for selective inhibition, is the substitution of isoleucine at position 523 in COX-1 with valine in COX-2. The smaller Val 523 residue in COX-2 allows access to a hydrophobic side-pocket in the enzyme (which Ile 523 ...
Edward Michael "Bear" Grylls OBE (/ ˈ ɡ r ɪ l z /; born 7 June 1974) is a British adventurer, writer, television presenter and former SAS trooper who is also a survival expert. He first drew attention after embarking on a number of notable adventures, including several world records in hostile environments, and then became widely known for his television series Man vs. Wild (2006–2011).
Box and Cox is a one act farce by John Maddison Morton. It is based on a French one-act vaudeville, Frisette, which had been produced in Paris in 1846. Box and Cox was first produced at the Lyceum Theatre, London, on 1 November 1847, billed as a "romance of real life." The play became popular and was revived frequently through the end of the ...