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Dexfenfluramine, formerly sold under the brand name Redux, is a serotonergic drug that was used as an appetite suppressant to promote weight loss. [3] It is the d-enantiomer of fenfluramine and is structurally similar to amphetamine, but lacks any psychologically stimulating effects.
Fenfluramine has been found to produce acute effects in humans including decreased arousal, elation, and positive mood, decreased anxiety at lower doses and increased anxiety at higher doses, drug disliking, confusion, reduced psychomotor performance, reduced impulsivity, and decreased aggression.
Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. [1] A 1984 study found a weight loss of 7.5 kg on average in 24 weeks, as compared to 4.4 kg under placebo. [4] It sold modestly until the 1990s, when it was combined with phentermine and heavily marketed. [1]
Because weight loss is a “side effect” of the diabetes drug, it’s also prescribed off-label for weight loss. This doesn’t mean it’s a quick fix, though. So, how long does it take ...
Clinical trials for exenatide demonstrated the potential of this diabetes drug for weight loss. Exenatide paved the way for future GLP-1s, providing new treatment options for people with obesity.
SGLT2 inhibitors cause the loss of 60–100 grams (2.1–3.5 oz) glucose in the urine each day and are associated with a modest, sustained weight loss of 1.5–2 kilograms (3.3–4.4 lb) in people with type 2 diabetes. The weight loss is less than expected due to compensatory increases in energy intake, but is additive when combined with GLP-1 ...
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