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In August 2023, the US Food and Drug Administration approved melphalan (Hepzato) as a liver-directed treatment for adults with uveal melanoma with unresectable hepatic metastases affecting less than 50% of the liver and no extrahepatic disease, or extrahepatic disease limited to the bone, lymph nodes, subcutaneous tissues, or lung that is ...
In the United States before market withdrawal, melphalan flufenamide was indicated in combination with dexamethasone for the treatment of adults with relapsed or refractory multiple myeloma, with relapsed or refractory multiple myeloma who have received at least four prior lines of therapy and whose disease is refractory to at least one proteasome inhibitor, one immunomodulatory agent, and one ...
Hodgkin disease, chronic leukimia, lung cancer, polycythemia vera, T-cell lymphoma, mycosia fungoides Hepatotoxicity (rare) [18] Melphalan: IV, PO: Alkylates DNA. Malignant melanoma of the extremities, multiple myeloma, conditioning treatment before haemopoietic stem cell transplant.
Examples include melphalan and chlorambucil. [6] The following three groups are almost always considered "classical". Nitrogen mustards [7] Cyclophosphamide — the most widely used alkylating agent of modern times; Chlormethine also known as mechlorethamine or mustine (HN2) — the first alkylating agent to receive regulatory approval
The Centers for Disease Control and Prevention (CDC) warns that those who consume sugary drinks like soda are more likely to experience health issues like obesity, type 2 diabetes, heart disease ...
Those included nausea and vomiting, kidney stones, gastroesophageal reflux disease (GERD), sleep issues, stomach cramps, pancreatitis, and gastroparesis (i.e. stomach paralysis).
A liver support system or diachysis is a type of therapeutic device to assist in performing the functions of the liver. Such systems focus either on removing the accumulating toxins (liver dialysis), or providing additional replacement of the metabolic functions of the liver through the inclusion of hepatocytes to the device (bioartificial liver device).
Churchwell said they can cause bronchial constriction, which can be a problem for people with chronic lung disease, asthma and diabetes. He added the drugs can mask symptoms of hypoglycemia as the ...