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The antimicrobial spectrum of an antibiotic can be determined by testing its antimicrobial activity against a wide range of microbes in vitro. Nonetheless, the range of microorganisms which an antibiotic can kill or inhibit in vivo may not always be the same as the antimicrobial spectrum based on data collected in vitro. [2] [5]
Oxazolidinones are useful as Evans auxiliaries, which are of interest for chiral synthesis. In a common implementation, an acid chloride substrate reacts with a chiral oxazolidinone to form an imide. Substituents at the 4 and 5 position of the oxazolidinone direct any aldol reaction to the alpha position of the carbonyl of the substrate. [6]
The oxazolidinone pharmacophore—the chemical "template" essential for antimicrobial activity—consists of a 1,3-oxazolidin-2-one moiety with an aryl group at position 3 and an S-methyl group, with another substituent attached to it, at position 5 (the R-enantiomers of all oxazolidinones are devoid of antibiotic properties). [108]
Skeletal formula of tetracycline with atoms and four rings numbered and labeled.. Tetracyclines are a group of broad-spectrum antibiotic compounds that have a common basic structure and are either isolated directly from several species of Streptomyces bacteria or produced semi-synthetically from those isolated compounds. [1]
Atmospheric pressure chemical ionization (APCI) is an ionization method used in mass spectrometry which utilizes gas-phase ion-molecule reactions at atmospheric pressure (10 5 Pa), [1] [2] commonly coupled with high-performance liquid chromatography (HPLC). [3]
A wash bottle is a squeeze bottle with a nozzle, used to rinse various pieces of laboratory glassware, such as test tubes and round bottom flasks. Wash bottles are sealed with a screw-top lid. When hand pressure is applied to the bottle, the liquid inside becomes pressurized and is forced out of the nozzle into a narrow stream of liquid.
According to Method 5210 in Standard Methods for the Examination of Water and Wastewater, the BOD bottle should include a ground-glass stopper and a flared mouth which form a water seal preventing the air from the outside of the bottle coming in. [1] Method 5210 also recommends to use a paper, a foil or a plastic cup to cap over the mouth of ...
Mariotte's bottle is a device that delivers a constant rate of flow from closed bottles or tanks. It is named after French physicist Edme Mariotte (1620-1684). A picture of a bottle with a gas inlet is shown in the works of Mariotte, [1] but this