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The activation of T H 1 and M1 macrophage is a positive feedback loop, with IFN-γ from T H 1 cells upregulating CD40 expression on macrophages; the interaction between CD40 on the macrophages and CD40L on T cells activate macrophages to secrete IL-12; and IL-12 promotes more IFN-γ secretion from T H 1 cells.
A macrophage's location can determine its size and appearance. Macrophages cause inflammation through the production of interleukin-1, interleukin-6, and TNF-alpha. [75] Macrophages are usually only found in tissue and are rarely seen in blood circulation. The life-span of tissue macrophages has been estimated to range from four to fifteen days ...
The mononuclear phagocyte system and the monocyte macrophage system refer to two different entities, often mistakenly understood as one. [ citation needed ] " Reticuloendothelial system " is an older term for the mononuclear phagocyte system, but it is used less commonly now, as it is understood that most endothelial cells are not macrophages .
General macrophage targets [10] [8] Kupffer cell: Monocyte: Macrophage: Stellate macrophages; Kupffer–Browicz cells; Liver macrophage; Macrophagocytus stellatus; 20-21 Foreign debris; General macrophage targets [11] [8] Alveolar macrophage: Monocyte: Macrophage: Pulmonary macrophage; Dust cell; 20-21 Carbon debris from lungs; General ...
Macrophages have a high antimicrobial and phagocytic activity and thereby protect tissues from foreign substances. They are cells that possess a large smooth nucleus, a large area of cytoplasm, and many internal vesicles for processing foreign material.
Through the release of Interleukin 4 (IL-4) and Interleukin 13 (IL-13) by TH2, or T helper cells, and mast cells, these macrophages can fuse to form foreign body giant cells. [1] [4] The macrophages are initially attracted to the injury/infection site through a variety of chemoattractants like growth factors, platelet factors, and interleukins. [4]
An alveolar macrophage, pulmonary macrophage, (or dust cell) is a type of macrophage, a professional phagocyte, found in the airways and at the level of the alveoli in the lungs, but separated from their walls.
Dermal macrophages are macrophages in the skin that facilitate skin homeostasis by mediating wound repair, hair growth, and salt balance. [1] Their functional role in these processes is the mediator of inflammation .
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