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N-acetylphosphatidylethanolamine-hydrolysing phospholipase D (EC 3.1.4.54, NAPE-PLD, anandamide-generating phospholipase D, N-acyl phosphatidylethanolamine phospholipase D, NAPE-hydrolyzing phospholipase D) is an enzyme with systematic name N-acetylphosphatidylethanolamine phosphatidohydrolase. [1] [2] It catalyses the following chemical reaction
N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) is an enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE). This is a major part of the process that converts ordinary lipids into chemical signals like anandamide and oleoylethanolamine .
A hydrophobic cavity in NAPE-PLD provides an entryway for the substrate NAPE into the active site, where a binuclear zinc center orchestrates its hydrolysis. Unexpectedly, the structure unveils bile acids bind the membrane enzyme, enhancing dimer assembly and enabling catalysis.
NAPE-PLD may refer to: N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D [ wikidata ] N-acyl phosphatidylethanolamine-specific phospholipase D , an enzyme
Liver cirrhosis can lead to increased intrahepatic vascular resistance and vasodilation of portal system arteries, both of which increase pressure in the portal vein. [4] Color Doppler Ultrasound is the most useful imaging tool used to identify aneurysms, thrombosis, and branching patterns of the portal venous system, and to determine if ...
In traditional Japanese culture, the nape (項, unaji) was one of the few areas of the body (other than face and hands) left uncovered by women's attire. The nape of a woman's neck held a strong attraction for many Japanese men (see oshiroi). [2] In Egyptian and Lebanese culture, slapping the nape is considered a gesture of utter humiliation. [3]
Ultrasonography (US) is the first-line imaging technique for the diagnosis and follow-up of portal hypertension because it is non-invasive, low-cost and can be performed on-site. [17] A dilated portal vein (diameter of greater than 13 or 15 mm) is a sign of portal hypertension, with a sensitivity estimated at 12.5% or 40%. [18]
Wyckoff Heights Medical Center is a 350-bed [1] teaching hospital located in the Wyckoff Heights section of Bushwick, Brooklyn in New York City.The hospital is an academic affiliate of the NewYork-Presbyterian's Weill Cornell Medical College of Cornell University, the New York Medical College and New York Institute of Technology College of Osteopathic Medicine.