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S-Methylmethionine (SMM) is a derivative of methionine with the chemical formula (CH 3) 2 S + CH 2 CH 2 CH(NH 3 +)CO 2 −.This cation is a naturally-occurring intermediate in many biosynthetic pathways owing to the sulfonium functional group.
Usually aminomethyl groups feature tertiary amines. Often they are obtained by alkylation with Eschenmoser's salt, a source of [CH 2 =N(CH 3) 2] +. A cobalt(III) complex of aminomethyl is known in the form [Co 2 (CH 2 NH 2)](ClO4) 2. [1] Aminomethyl is the first member of a series of 1-aminoalkyl groups of the form −(CH 2 −) n NH 2. [2]
Moreover, 3-hydroxymethyl-beta-carboline blocks the sleep-promoting effect of flurazepam in rodents and – by itself – can decrease sleep in a dose-dependent manner. [16] Another derivative, methyl-β-carboline-3-carboxylate, stimulates learning and memory at low doses but can promote anxiety and convulsions at high doses. [15]
3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid is used in the manufacture of six commercial fungicides which are inhibitors of succinate dehydrogenase. [20] [21] Pyrazole is an inhibitor of the alcohol dehydrogenase enzyme, and, as such, is used as an adjuvant with ethanol, to induce alcohol dependency in experimental laboratory mice ...
SR9009, also known as Stenabolic, is a research drug that was developed by professor Thomas Burris of the Scripps Research Institute as an agonist of Rev-ErbA (i.e., increases the constitutive repression of genes regulated by Rev-ErbA) [1] with a half-maximum inhibitory concentration (IC 50) = 670 nM for Rev-ErbAα and IC 50 = 800 nM for Rev-ErbAβ. [2]
3,5-Dimethylpyrazole is an organic compound with the formula (CH 3 C) 2 CHN 2 H. It is one of several isomeric derivatives of pyrazole that contain two methyl substituents. The compound is unsymmetrical but the corresponding conjugate acid (pyrazolium) and conjugate base (pyrazolide) have C 2v symmetry. It is a white solid that dissolves well ...
Isonicotinic acid or pyridine-4-carboxylic acid is an organic compound with the formula C 5 H 4 N(CO 2 H). It is a derivative of pyridine with a carboxylic acid substituent at the 4-position. It is an isomer of picolinic acid and nicotinic acid , which have the carboxyl group at the 2- and 3-position respectively compared to the 4-position for ...
N-Methyl-3-piperidyl benzilate (JB-336, BZ) Piperidine is also commonly used in chemical degradation reactions, such as the sequencing of DNA in the cleavage of particular modified nucleotides. Piperidine is also commonly used as a base for the deprotection of Fmoc-amino acids used in solid-phase peptide synthesis.