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  2. Fischer–Speier esterification - Wikipedia

    en.wikipedia.org/wiki/Fischer–Speier...

    Examples of this [contradictory] include the common undergraduate organic lab experiment involving the acetylation of salicylic acid to yield aspirin. Fischer esterification is primarily a thermodynamically-controlled process: because of its slowness, the most stable ester tends to be the major product. This can be a desirable trait if there ...

  3. Aspirin - Wikipedia

    en.wikipedia.org/wiki/Aspirin

    Aspirin is readily broken down in the body to salicylic acid, which itself has anti-inflammatory, antipyretic, and analgesic effects. In 2012, salicylic acid was found to activate AMP-activated protein kinase, which has been suggested as a possible explanation for some of the effects of both salicylic acid and aspirin.

  4. Salicylic acid - Wikipedia

    en.wikipedia.org/wiki/Salicylic_acid

    Salicylic acid is an organic compound with the formula HOC 6 H 4 COOH. [3] A colorless (or white), bitter-tasting solid, it is a precursor to and a metabolite of acetylsalicylic acid (aspirin). [3]

  5. Mechanism of action of aspirin - Wikipedia

    en.wikipedia.org/wiki/Mechanism_of_action_of_aspirin

    Also visible is the salicylic acid which has transferred the acetyl group, and the heme cofactor. There are at least two different cyclooxygenase isozymes: COX-1 (PTGS1) and COX-2 (PTGS2). Aspirin is non-selective and irreversibly inhibits both forms [4] (but is weakly more selective for COX-1 [5]).

  6. Kolbe–Schmitt reaction - Wikipedia

    en.wikipedia.org/wiki/Kolbe–Schmitt_reaction

    The Kolbe–Schmitt reaction proceeds via the nucleophilic addition of a phenoxide, classically sodium phenoxide (NaOC 6 H 5), to carbon dioxide to give the salicylate. The final step is the reaction (protonation) of the salicylate anion with an acid to form the desired salicylic acids (ortho- and para- isomers).

  7. Copper aspirinate - Wikipedia

    en.wikipedia.org/wiki/Copper_aspirinate

    Copper aspirinate can be prepared by several methods. In one route of preparation, an excess of acetylsalicylic acid is dissolved in aqueous sodium carbonate. Sodium hydroxide is not suitable for this purpose, because it will hydrolyse acetylsalicylic acid (ASA) into salicylic acid and sodium acetate. 2 HC 9 H 7 O 4 + Na 2 CO 3 → 2 NaC 9 H 7 ...

  8. Lysine acetylsalicylate - Wikipedia

    en.wikipedia.org/wiki/Lysine_acetylsalicylate

    The therapeutic effects of salicylic acids were first documented in 1763 by Edward Stone, with acetylsalicylic acid being synthesized by Felix Hoffmann, a chemist working under Bayer, in 1897. [4] Acetylsalicylic acid-derived salt compounds were first discovered in 1970, [5] and the synthesis of lysine acetylsalicylate was first documented in ...

  9. Salicylate poisoning - Wikipedia

    en.wikipedia.org/wiki/Salicylate_poisoning

    Salicylate poisoning, also known as aspirin poisoning, is the acute or chronic poisoning with a salicylate such as aspirin. [1] The classic symptoms are ringing in the ears , nausea , abdominal pain , and a fast breathing rate . [ 1 ]