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[22] [23] Metoprolol may also cause the hands and feet to feel cold. [24] Due to the high penetration across the blood–brain barrier , lipophilic beta blockers such as propranolol and metoprolol are more likely than other less lipophilic beta blockers to cause sleep disturbances such as insomnia, vivid dreams and nightmares. [ 25 ]
Swollen legs, feet and ankles are common in late pregnancy. The problem is partly caused by the weight of the uterus on the major veins of the pelvis . It usually clears up after delivery of the baby, and is mostly not a cause for concern, [ 16 ] though it should always be reported to a doctor.
The condition is commonly associated with vascular and cardiac changes associated with aging but can be caused by many other conditions, including congestive heart failure, kidney failure, liver cirrhosis, portal hypertension, trauma, alcoholism, altitude sickness, pregnancy, hypertension, sickle cell anemia, a compromised lymphatic system or merely long periods of time sitting or standing ...
Other rheumatological disorders that can cause the features typical for RS3PE include late onset (seronegative) rheumatoid arthritis, acute sarcoidosis, ankylosing spondylitis and other spondyloarthropathies such as psoriatic arthropathy, mixed connective tissue disease, chondrocalcinosis and arthropathy due to amyloidosis. [6] [9]
Kidney function gradually decreases as someone ages. The elderly are also likely to be underweight. In addition, these older people tend to be dehydrated and be taking other medications. These factors increase the likelihood of developing side effects of digoxin and digoxin toxicity. Often lowering the dose is considered by the prescriber. [6]
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Standing places significant pressure on the joint of the hips, knees, ankle and feet but without any significant movement of it. [9] This reduces the normal lubrication and cushioning of synovial joints, causing them to tear. The combined effect of pressure and tearing can cause extensive amounts of pain and make it difficult to move or walk. [3]
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