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1949: "The Inheritance of Sickle Cell Anemia"- Published in Science 110: 64-66, this paper explored how a single gene mutation is responsible for the inheritance of sickle cell anemia. Neel's research and analysis supported the pattern of a mutation occurrence in the hemoglobin subunit β (HHB gene) which is responsible for providing ...
Hakulinen E (March 1990). "The man behind the syndrome. James B Herrick: the discoverer of sickle cell anemia. His first case report received scant interest--only in the 1950s was the role of "moon-crescent" shape considered" [The man behind the syndrome. James B Herrick: the discoverer of sickle cell anemia.
Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders that are typically inherited. [2] The most common type is known as sickle cell anemia. [2] Sickle cell anemia results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. [2]
"Sickle Cell Anemia, a Molecular Disease" is a 1949 scientific paper by Linus Pauling, Harvey A. Itano, Seymour J. Singer and Ibert C. Wells that established sickle-cell anemia as a genetic disease in which affected individuals have a different form of the metalloprotein hemoglobin in their blood.
In fact, it was only in the 1940s when researcher Linus Pauling and his team discovered the causes of sickle cell anemia and its hereditary nature — both parents had to pass on the sickle cell ...
While at Caltech, Itano joined the lab of Linus Pauling and began working on sickle cell anemia, a genetic disease that Pauling was interested in. [4] Pauling was convinced that sickle cell disease was caused by defective hemoglobin, and set Itano to find out what made sickle cell hemoglobin chemically different. [9]
In November 1949, Pauling, Harvey Itano, S. J. Singer and Ibert Wells published "Sickle Cell Anemia, a Molecular Disease" [66] in the journal Science. It was the first proof of a human disease being caused by an abnormal protein, and sickle cell anemia became the first disease understood at the
This culminated in his most influential publication, "Immunologic Studies in Sickle Cell Anemia". [1] This work concluded that sickle cell anemia is most common among people of African heritage, that not all people with sickle cell anemia are anemic, that not all sickle cell cases are fatal, and that sickle cell anemia is a Mendelian trait. [6]
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