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Referring to a common salt of fluoride, sodium fluoride (NaF), the lethal dose for most adult humans is estimated at 5 to 10 g (which is equivalent to 32 to 64 mg elemental fluoride/kg body weight). [ 2 ] [ 3 ] [ 4 ] Ingestion of fluoride can produce gastrointestinal discomfort at doses at least 15 to 20 times lower (0.2–0.3 mg/kg or 10 to 15 ...
Other symptoms include thickening of the bone structure and accumulation of bone tissue, which both contribute to impaired joint mobility. Ligaments and cartilage can become ossified. [2] Most patients with skeletal fluorosis show side effects from the high fluoride dose such as ruptures of the stomach lining and nausea. [3]
Increased exposure of fluoride may lead to certain adverse side effects, including dental fluorosis and developmental neurotoxicity. [5] [6] Other rare side effects include skin rash and hypersensitivity reactions. [7] In severe cases, fluoride overdose may lead to acute toxicity. [6] [19] Dental fluorosis with white marks on teeth
Other symptoms to note: Drug rashes can be a side effect of or a reaction to a new medication; almost any medication can cause a drug rash, but antibiotics and NSAIDs are the most common culprits ...
In fact, 75% of fluoride intake comes from drinking water with added fluoride and from food and beverages, such as sodas and fruit juice, made with fluoridated water, according to the CDC.
Fluoride therapy is the use of fluoride for medical purposes. [2] Fluoride supplements are recommended to prevent tooth decay in children older than six months in areas where the drinking water is low in fluoride. [3] It is typically used as a liquid, pill, or paste by mouth. [4] Fluoride has also been used to treat a number of bone diseases. [5]
Fluoride or fluorine deficiency is a disorder which may cause increased dental caries [1] and possibly osteoporosis, [2] [3] due to a lack of fluoride in diet. [4] [5] Common dietary sources of fluoride include tea, grape juice, wine, raisins, some seafood, coffee, and tap water that has been fluoridated. [6]
The dose that may lead to adverse health effects is about one fifth of the lethal dose. [69] Chronic excess fluoride consumption can lead to skeletal fluorosis, a disease of the bones that affects millions in Asia and Africa. [69] [70] The fluoride ion is readily absorbed by the stomach and intestines.