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Carbon-14, C-14, 14 C or radiocarbon, is a radioactive isotope of carbon with an atomic nucleus containing 6 protons and 8 neutrons. Its presence in organic matter is the basis of the radiocarbon dating method pioneered by Willard Libby and colleagues (1949) to date archaeological, geological and hydrogeological samples.
Carbon-14 labeling is common in drug development to do ADME (absorption, distribution, metabolism and excretion) studies in animal models and in human toxicology and clinical trials. Since tritium exchange may occur in some radiolabeled compounds, this does not happen with carbon-14 and may thus be preferred.
Two are stable and not radioactive: carbon-12 (12 C), and carbon-13 (13 C); and carbon-14 (14 C), also known as "radiocarbon", which is radioactive. The half-life of 14 C (the time it takes for half of a given amount of 14 C to decay) is about 5,730 years, so its concentration in the atmosphere might be expected to decrease over thousands of ...
All living cells contain both DNA and RNA (except some cells such as mature red blood cells), while viruses contain either DNA or RNA, but usually not both. [15] The basic component of biological nucleic acids is the nucleotide , each of which contains a pentose sugar ( ribose or deoxyribose ), a phosphate group, and a nucleobase . [ 16 ]
It can displace potassium in humans affecting the central nervous system. Thallium poisoning has a long history in humans, especially as it has sometimes been a preferred poison. thorium: 90: 1b: Has no known biological role. [11] Radioactive. thulium: 69: 2a: No known function in humans, and is not taken up by plants. [11] Toxic in some forms ...
Radioactive nonprimordial, but naturally occurring on Earth. 61 347 Carbon-14 (and other isotopes generated by cosmic rays) and daughters of radioactive primordial elements, such as radium, polonium, etc. 41 of these have a half life of greater than one hour. Radioactive synthetic half-life ≥ 1.0 hour). Includes most useful radiotracers. 662 989
The effects of radiation on cells has been found to be dependent on the dosage of the radiation, the location of the cell in regards to tissue, and whether the cell is a somatic or germ line cell. Generally, ionizing radiation appears to reduce methylation of DNA in cells.
DNA exists in many possible conformations that include A-DNA, B-DNA, and Z-DNA forms, although only B-DNA and Z-DNA have been directly observed in functional organisms. [14] The conformation that DNA adopts depends on the hydration level, DNA sequence, the amount and direction of supercoiling, chemical modifications of the bases, the type and ...