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These findings [5] suggested that there is a PKA-dependent phase of LTP intermediate to E-LTP and L-LTP, which was called intermediate LTP (I-LTP). In the transgenic mice, on the other hand, LTP induced by two trains decayed faster than in wild-type mice, implying that excessive calcineurin activity suppresses both I-LTP and L-LTP.
Alzheimer's disease is a progressive neurodegenerative disorder associated with aging, which occurs both sporadically (the most common form of diagnosis) or due to familial passed mutations in genes associated with Alzheimer's pathology. [1] [2] Common symptoms associated with Alzheimer's disease include: memory loss, confusion, and mood ...
HEPPS (EPPS) is a buffering agent used in biology and biochemistry.The pKa of HEPPS is 8.00. It is ones of Good's buffers. [1]Research on mice with Alzheimer's disease-like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice.
Alzheimer's disease has been identified as a protein misfolding disease, or proteopathy, due to the accumulation of abnormally folded amyloid-beta proteins in the brains of AD patients. [1] Abnormal amyloid-beta accumulation can first be detected using cerebrospinal fluid analysis and later using positron emission tomography (PET).
In cell biology, protein kinase A (PKA) is a family of serine-threonine kinase [1] whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase (EC 2.7.11.11). PKA has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.
4804 18053 Ensembl ENSG00000064300 ENSMUSG00000000120 UniProt P08138 Q9Z0W1 RefSeq (mRNA) NM_002507 NM_033217 RefSeq (protein) NP_002498 NP_150086 Location (UCSC) Chr 17: 49.5 – 49.52 Mb Chr 11: 95.46 – 95.48 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR ...
Several Epac-selective cAMP analogs have been developed to clarify the functional roles of Epacs as well those of the Epac-dependent signaling pathway distinct from the PKA-dependent signaling pathway. [17] The modifications of 8-position in the purine structure and 2’-position in ribose is considered to be crucial to the specificity for Epacs.
Zhenyu Yue's research has primarily concentrated on the molecular and cellular mechanisms underlying neurodegenerative diseases, with a particular focus on Parkinson’s disease and Alzheimer’s disease. [9] One of the notable areas of Yue's research involves the study of autophagy, a cellular process that degrades and recycles cellular ...
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