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STR analysis is a tool in forensic analysis that evaluates specific STR regions found on nuclear DNA. The variable (polymorphic) nature of the STR regions that are analyzed for forensic testing intensifies the discrimination between one DNA profile and another. [3] Scientific tools such as FBI approved STRmix incorporate this research technique.
The basis for the profile probability estimation for Y-STR analysis is the counting method. [4] The application of a confidence interval accounts for database size and sampling variation. The Y haplotype frequency (p) is calculated using the p = x/N formula, where x is equal to the number of times the haplotype is observed in a database ...
Python: Python profiling includes the profile module, hotshot (which is call-graph based), and using the 'sys.setprofile' function to trap events like c_{call,return,exception}, python_{call,return,exception}. Ruby: Ruby also uses a similar interface to Python for profiling. Flat-profiler in profile.rb, module, and ruby-prof a C-extension are ...
In computer programming, profile-guided optimization (PGO, sometimes pronounced as pogo [1]), also known as profile-directed feedback (PDF) [2] or feedback-directed optimization (FDO), [3] is the compiler optimization technique of using prior analyses of software artifacts or behaviors ("profiling") to improve the expected runtime performance of the program.
The microsatellite mutation rate in human male germ lines is five to six times higher than in female germ lines and ranges from 0 to 7 × 10 −3 per locus per gamete per generation. [3] In the nematode Pristionchus pacificus , the estimated microsatellite mutation rate ranges from 8.9 × 10 −5 to 7.5 × 10 −4 per locus per generation.
The Y-STR markers in the following list are commonly used in forensic [1] and genealogical DNA testing. DYS454 is the least diverse, and multi-copy marker DYS464 is the most diverse Y-STR marker. The location on the Y-chromosome of numbered Y-STR markers can be roughly given with cytogenetic localization. For example, DYS449 is located at Yp11 ...
A sequence profiling tool in bioinformatics is a type of software that presents information related to a genetic sequence, gene name, or keyword input. Such tools generally take a query such as a DNA , RNA , or protein sequence or ‘keyword’ and search one or more databases for information related to that sequence.
STR polymorphisms are genetic markers that may be used to identify a DNA sequence. The FBI analyses 13 specific STR loci for their database. These may be used in many areas of genetics in addition to their forensic uses. One can think of a STR multiplex system as a collection of specific STRs which are positionally conserved on a target genome.