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Tucidinostat (INN, also known as chidamide and sold under the brand names Epidaza and Hiyasta) is a histone deacetylase inhibitor (HDI) developed in China. [1] It was also known as HBI-8000 . [ 2 ] It is a benzamide HDI and inhibits Class I HDAC1 , HDAC2 , HDAC3 , as well as Class IIb HDAC10 .
55-21-0 3D model ... 1.341 g/cm 3: Melting point: 127 to 130 °C (261 to 266 °F; 400 to 403 K) ... Benzamide is an organic compound with the chemical formula of C 7 ...
Lisaftoclax is an investigational new drug being developed by Ascentage Pharma for the treatment of hematological malignancies, particularly chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL).
Benzamidine is an organic compound with the formula C 6 H 5 C(NH)NH 2. It is the simplest aryl amidine. The compound is a white solid that is slightly soluble in water. It is usually handled as the hydrochloride salt, a white, water-soluble solid. [2]
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U-77891 is an opioid analgesic drug that was first synthesized in 1983 by the Upjohn company. [1] It was originally synthesized to prove that the removal of a single methylene spacer of the benzamide would alter a κ-opioid receptor agonist such as U-50488 into an μ-opioid receptor agonist, as well as producing a semi-rigid derivative of U-47700.
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Alkylation of the sodium salt of p-hydroxybenzaldehyde (1) with 2-dimethylaminoethyl chloride affords the ether (2). Reductive amination of the aldehyde in the presence of ammonia gives diamine (3). Acylation of that product with 3,4,5-trimethoxybenzoyl chloride affords trimethobenzamide (4).