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Selenomethionine (SeMet) is a naturally occurring amino acid. The L -selenomethionine enantiomer is the main form of selenium found in Brazil nuts , cereal grains , soybeans , and grassland legumes , while Se -methylselenocysteine , or its γ-glutamyl derivative , is the major form of selenium found in Astragalus , Allium , and Brassica species ...
Selenium yeast is a feed additive for livestock, used to increase the selenium content in their fodder. It is a form of selenium currently approved for human consumption in the EU and Britain. [ 1 ] Inorganic forms of selenium are used in feeds (namely sodium selenate and sodium selenite , which appear to work in roughly the same manner).
For example, selenomethionine and selenocysteine are selenium-containing amino acids present in the human body. Selenomethionine participates in the synthesis of selenoproteins . [ 2 ] The reduction potential and pKa (5.47) of selenocysteine are lower than those of cysteine , making some proteins have antioxidant activity. [ 3 ]
Selenium is a component of the amino acids selenocysteine and selenomethionine. In humans, selenium is a trace element nutrient that functions as cofactor for glutathione peroxidases and certain forms of thioredoxin reductase. [1] Selenium-containing proteins are produced from inorganic selenium via the intermediacy of selenophosphate (PSeO 3 3 ...
Selenium is toxic in high concentrations. As sodium selenite, the chronic toxic dose for human beings was described as about 2.4 to 3 milligrams of selenium per day. [7] In 2000, the US Institute of Medicine set the adult Tolerable upper intake levels (UL) for selenium from all sources - food, drinking water and dietary supplements - at 400 μg/day. [8]
Selenocysteine is an analogue of the more common cysteine with selenium in place of the sulfur. Selenocysteine is present in several enzymes (for example glutathione peroxidases , tetraiodothyronine 5′ deiodinases , thioredoxin reductases , formate dehydrogenases , glycine reductases , selenophosphate synthetase 2 , methionine- R -sulfoxide ...
Methylselenocysteine, also known as Se-methylselenocysteine, is an analog of S-methylcysteine in which the sulfur atom is replaced with a selenium atom. It is an inhibitor of DMBA-induced mammary tumors [1] and a "chemopreventive agent that blocks cell cycle progression and proliferation of premalignant mammary lesions and induces apoptosis of cancer cell lines in culture."
Methaneselenol (commonly named "methylselenol") (CH 3 SeH), which can be produced in vitro by incubating selenomethionine with a bacterial methionine gamma-lyase (METase) enzyme, by biological methylation of selenide ion or in vivo by reduction of methaneseleninic acid (CH 3 −Se(=O)−OH), has been invoked to explain the anticancer activity ...
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