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  2. Somatostatin - Wikipedia

    en.wikipedia.org/wiki/Somatostatin

    Somatostatin is secreted by delta cells at several locations in the digestive system, namely the pyloric antrum, the duodenum and the pancreatic islets. [14]Somatostatin released in the pyloric antrum travels via the portal venous system to the heart, then enters the systemic circulation to reach the locations where it will exert its inhibitory effects.

  3. Jean Louisa Kelly - Wikipedia

    en.wikipedia.org/wiki/Jean_Louisa_Kelly

    Jean Louisa Kelly (born March 9, 1972) is an American actress and singer. After making her film debut as Tia Russell in Uncle Buck (1989) alongside John Candy, she appeared in a wide range of other films including The Fantasticks (1995) and Mr. Holland's Opus (1995).

  4. Somatostatin inhibitor - Wikipedia

    en.wikipedia.org/wiki/Somatostatin_inhibitor

    It is a non-selective somatostatin receptor antagonist, [37] inhibiting the effects of somatostatin on target cells in the gastrointestinal tract, pancreas, hypothalamus, and central nervous system. [2] Cyclosomatostatin is used as a research chemical to investigate the effects of somatostatin on different cell types by antagonizing its ...

  5. Somatostatin receptor antagonist - Wikipedia

    en.wikipedia.org/wiki/Somatostatin_receptor...

    Somatostatin receptor antagonists (or somatostatin inhibitors) are a class of chemical compounds that work by imitating the structure of the neuropeptide somatostatin. The somatostatin receptors are G protein-coupled receptors. Somatostatin receptor subtypes in humans are sstr1, 2A, 2 B, 3, 4 and 5. [1]

  6. Somatostatin receptor 3 - Wikipedia

    en.wikipedia.org/wiki/Somatostatin_receptor_3

    20607 Ensembl ENSG00000278195 ENSMUSG00000044933 UniProt P32745 P30935 RefSeq (mRNA) NM_001051 NM_001278687 NM_009218 NM_001356961 RefSeq (protein) NP_001042 NP_001265616 NP_033244 NP_001343890 Location (UCSC) Chr 22: 37.2 – 37.21 Mb Chr 15: 78.42 – 78.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Shekel Somatostatin receptor type 3 is a protein that in humans is encoded by ...

  7. Somatostatin receptor 2 - Wikipedia

    en.wikipedia.org/wiki/Somatostatin_receptor_2

    The somatostatin hormone itself can negatively affect the uptake of hormones in the body and may play a role in some hormonal conditions. Somatostatin 2 receptors have been found in concentration on the surface of tumor cells, particularly those associated with the neuroendocrine system where the overexpression of somatostatin can lead to many complications [22] [23] Due to this, these ...

  8. John Hughes (filmmaker) - Wikipedia

    en.wikipedia.org/wiki/John_Hughes_(filmmaker)

    Actor John Candy created many memorable roles in films written, directed or produced by Hughes, including National Lampoon's Vacation (1983), Planes, Trains and Automobiles (1987), The Great Outdoors (1988), Uncle Buck (1989), Home Alone (1990), Career Opportunities and Only the Lonely (both 1991). Over the years, Hughes and Candy developed a ...

  9. John Candy - Wikipedia

    en.wikipedia.org/wiki/John_Candy

    John Franklin Candy (October 31, 1950 – March 4, 1994) [1] was a Canadian actor and comedian who is best known for his work in Hollywood films. Candy first rose to national prominence in the 1970s as a member of the Toronto branch of the Second City and its SCTV sketch comedy series .