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The term variant of concern (VOC) for SARS-CoV-2, which causes COVID-19, is a category used for variants of the virus where mutations in their spike protein receptor binding domain (RBD) substantially increase binding affinity (e.g., N501Y) in RBD-hACE2 complex (genetic data), while also being linked to rapid spread in human populations ...
Distinct from the PANGOLIN tool, Pango lineages are regularly, manually curated based on the current globally circulating diversity. A large phylogenetic tree is constructed from an alignment containing publicly available SARS-CoV-2 genomes, and sub-clusters of sequences in this tree are manually examined and cross-referenced against epidemiological information to designate new lineages; these ...
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“Variants that can infect people better or evade immunity to the last variant are more likely to cause a new COVID wave,” Peter Kasson, M.D., Ph.D., B.S., of the University of Virginia’s ...
Lineage B.1.617 is a lineage of SARS-CoV-2, the virus that causes COVID-19. [1] It first came to international attention in late March 2021 after the newly established INSACOG performed genome sequencing on positive samples throughout various Indian states.
FLiRT variants are subvariants of omicron and were responsible for most COVID-19 cases in the U.S. by the beginning of July 2024. The KP.1 and KP.2 strains of FLiRT are the dominant strains of the ...
False-colour transmission electron micrograph of a B.1.1.7 variant coronavirus. The variant's increased transmissibility is believed to be due to changes in the structure of the spike proteins, shown here in green. There are many thousands of variants of SARS-CoV-2, which can be grouped into the much larger clades. [142]
Theta variant, also known as lineage P.3, [a] is one of the variants of SARS-CoV-2, the virus that causes COVID-19. The variant was first identified in the Philippines on February 18, 2021, when two mutations of concern were detected in Central Visayas . [ 1 ]