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Posterior cortical atrophy (PCA), also called Benson's syndrome, is a rare form of dementia which is considered a visual variant or an atypical variant of Alzheimer's disease (AD). [ 1 ] [ 2 ] [ 3 ] The disease causes atrophy of the posterior part of the cerebral cortex , resulting in the progressive disruption of complex visual processing . [ 4 ]
LTP in Alzheimer's disease [ edit ] It is known that Alzheimer's disease is characterized by extracellular deposits of neurotoxic amyloid peptides (Aβ), intracellular aggregation of hyper-phosphorylated tau protein, and neuronal death. [ 10 ]
Misprocessing of amyloid precursor protein (APP) in Alzheimer's disease disrupts LTP and is thought to lead to early cognitive decline in individuals with the disease. [ 64 ] LTP has received much attention among those who study Alzheimer's disease (AD), a neurodegenerative disease that causes marked cognitive decline and dementia .
3-Indolepropionic acid (IPA), or indole-3-propionic acid, has been studied for its therapeutic value in the treatment of Alzheimer's disease.As of 2022 [3] IPA shows potential in the treatment of this disease, though the therapeutic effect of IPA depends on dose and time of therapy initiation.
In cell biology, protein kinase A (PKA) is a family of serine-threonine kinase [1] whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase (EC 2.7.11.11). PKA has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.
It is believed that the new technology will provide not only future early diagnosis of Alzheimer's disease but also possible therapy for Alzheimer's disease. An open international study group (ND.Neuromark.net) has been constituted for arranging scientific information and developing a rational guide for implementing biomarkers into routine ...
Tropoflavin, also known as 7,8-dihydroxyflavone (DHF), is a naturally occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. [2] [3] [4] It has been found to act as a potent and selective small-molecule agonist of the tropomyosin receptor kinase B (TrkB) (K d ≈ 320 nM), the main signaling receptor of the neurotrophin brain-derived neurotrophic factor ...
Abnormal accumulation of tau protein, which constitutes neurofibrillary tangles, in neuronal cell bodies (arrow) and neuronal extensions (arrowhead) in the neocortex of a patient who had died with Alzheimer's disease at Braak stage VI. The bar = 25 microns (0.025 millimeters). Staging in Alzheimer's disease was described by Braak in 1991. [8]
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