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Asthma is a common pulmonary condition defined by chronic inflammation of respiratory tubes, tightening of respiratory smooth muscle, and episodes of bronchoconstriction. [1] The Centers for Disease Control and Prevention estimate that 1 in 11 children and 1 in 12 adults have asthma in the United States of America. [ 1 ]
Anatomy photo:19:st-1001 at the SUNY Downstate Medical Center - "Pleural Cavities and Lungs: Bronchopulmonary segments" Illustration at uams.edu; Sealy W, Connally S, Dalton M (1993). "Naming the bronchopulmonary segments and the development of pulmonary surgery". Ann Thorac Surg. 55 (1): 184– 8. doi: 10.1016/0003-4975(93)90507-E. PMID 8417676.
The respiratory bronchioles deliver air to the exchange surfaces of the lungs. [5] They are interrupted by alveoli which are thin walled evaginations. Alveolar ducts are side branches of the respiratory bronchioles. The respiratory bronchioles are lined by ciliated cuboidal epithelium along with some non-ciliated cells called club cells. [6]
Asthma phenotyping and endotyping has emerged as a novel approach to asthma classification inspired by precision medicine which separates the clinical presentations of asthma, or asthma phenotypes, from their underlying causes, or asthma endotypes. The best-supported endotypic distinction is the type 2-high/type 2-low distinction.
The lower airways or lower respiratory tract includes the portion of the larynx below the vocal folds, trachea, bronchi and bronchioles. The lungs can be included in the lower respiratory tract or as separate entity and include the respiratory bronchioles, alveolar ducts, alveolar sacs, and alveoli. [3] Adult and pediatric airway anatomy
The respiratory system (also respiratory apparatus, ventilatory system) is a biological system consisting of specific organs and structures used for gas exchange in animals and plants. The anatomy and physiology that make this happen varies greatly, depending on the size of the organism, the environment in which it lives and its evolutionary ...
For the respiratory system to function properly, there need to be as few impediments as possible to the movement of air within the lungs. Inflammation of the lungs and excess mucus are common sources of breathing difficulties. [50] In asthma, the respiratory system is persistently inflamed, causing wheezing or shortness of breath.
This can disrupt the normal physiology of the lung and predispose to respiratory diseases. Severe nutritional deficiency in vitamin A results in a reduction in the formation of the alveolar walls (septa) and to notable changes in the respiratory epithelium; alterations are noted in the extracellular matrix and in the protein content of the ...