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Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus bacterium of the genus Bordetella, and the causative agent of pertussis or whooping cough. Its virulence factors include pertussis toxin , adenylate cyclase toxin , filamentous haemagglutinin , pertactin , fimbria , and tracheal cytotoxin .
Two of these (B. pertussis and B. bronchiseptica) are also motile. [3] [4] There are about 16 different species of Bordetella likely descending from ancestors who lived in soil and/or water environments. [5] B. pertussis and occasionally B. parapertussis cause pertussis (whooping cough) in humans, and some B. parapertussis strains only colonize ...
Whooping cough (/ ˈ h uː p ɪ ŋ / or / ˈ w uː p ɪ ŋ /), also known as pertussis or the 100-day cough, is a highly contagious, vaccine-preventable bacterial disease. [1] [10] Initial symptoms are usually similar to those of the common cold with a runny nose, fever, and mild cough, but these are followed by two or three months of severe coughing fits. [1]
Whooping cough bacteria Bordetella pertussis in human airways; nurse prepares syringe with vaccine against whooping cough; Migrants from the southern border being dropped of at Trenton ...
Pertussis was well known throughout Europe by the middle of the 18th century. Jules Bordet and Octave Gengou described in 1900 the finding of a new “ovoid bacillus” in the sputum of a 6-month-old infant with whooping cough. They were also the first to cultivate Bordetella pertussis at the Pasteur Institute in Brussels in 1906. [9]
Adenylate cyclase toxin from Bordetella pertussis is a 1706 amino acid residue long protein.The protein consists of three domains: from the N-terminus up to roughly residue 400, there is an adenylate-cyclase domain; between residues 500 and 700, there is a hydrophobic domain; and from residue 1000 to the C-terminus, there are calcium binding repeats.
European countries have reported a surge in whooping cough cases in 2023 and the first quarter of 2024, with 10 times as many identified as in each of the previous two years. In total, nearly ...
PRN is purified from Bordetella pertussis and is used for the vaccine production as one of the important components of acellular pertussis vaccine. [2] A large part of the N-terminus of the pertactin protein is composed of beta helix repeats. [3] This region of the pertactin protein is secreted through the C-terminal autotransporter.