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Some of these uses include acne, seborrhea, hirsutism, and pattern hair loss in women. [38] Spironolactone is used for the treatment of hirsutism in the United States. [39] High doses of spironolactone, which are needed for considerable antiandrogenic effects, are not recommended for men due to the high risk of feminization and other side effects.
Androgen receptor antagonistic potency of spironolactone, cyproterone acetate, and flutamide in castrated male rats treated with exogenous testosterone (as measured by inhibition of androgen-dependent ventral prostate weight). [27] Spironolactone is an antagonist of the AR, the biological target of androgens like testosterone and DHT.
Weight gain or weight loss. ... Spironolactone, a prescription diuretic medication that’s FDA-approved for heart failure and high blood pressure that also has anti-androgen effects. It is often ...
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Aldosterone antagonists: spironolactone, which is a competitive antagonist of aldosterone. Aldosterone normally adds sodium channels in the principal cells of the collecting duct and late distal tubule of the nephron. Spironolactone prevents aldosterone from entering the principal cells, preventing sodium reabsorption.
For those with signs of hyperandrogenism (excessive androgen hormones) and other hormonal imbalances, spironolactone may be an effective treatment for female pattern hair loss. Spironolactone ...