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Spironolactone. Spironolactone is a once-a-day tablet that can stop hair loss from progressing and encourage new hair growth. ... If you have an infection or inflammation that’s causing hair ...
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Spironolactone can be used in the treatment of female-pattern hair loss (pattern scalp hair loss in women). [69] There is tentative low quality evidence supporting its use for this indication. [70] Although apparently effective, not all cases of female-pattern hair loss are dependent on androgens. [71]
They found the gene P2RY5 causes a rare, inherited form of hair loss called hypotrichosis simplex. It is the first receptor in humans known to play a role in hair growth. [ 103 ] [ 104 ] [ 105 ] Researchers found that disruption of the gene SOX21 in mice caused cyclical hair loss.
The AR antagonism of spironolactone mostly underlies its antiandrogenic activity and is the major mechanism responsible for its therapeutic benefits in the treatment of androgen-dependent conditions like acne, hirsutism, and pattern hair loss and its usefulness in hormone therapy for transgender women.
A prescription medication, spironolactone blocks androgen production that decreases the amount of DHT, the hormone that causes hair follicles to shrink and hair shafts to become thinner and finer.
The most common cause is androgenetic alopecia, also known as male pattern or female pattern hair loss due to the effects of dihydrotestosterone (DHT) on the hair follicles. A variety of factors may lead to this condition such as hormonal effects , age, diet, autoimmunity , emotional stress, physical stress, drug effects, genetics , or infections .