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[1] [40] [41] Addison's can affect persons of any age, sex, or ethnicity, but it typically presents in adults between 30 and 50 years of age. [41] [42] Research has shown no significant predispositions based on ethnicity. [40] About 70% of Addison's disease diagnoses occur due to autoimmune reactions, which cause damage to the adrenal cortex. [5]
Most people with primary Addison's disease have darkening (hyperpigmentation) of the skin, including areas not exposed to the sun; characteristic sites are skin creases (e.g. of the hands), nipple, and the inside of the cheek (buccal mucosa), new scars become hyperpigmented, whereas older ones do not darken.
A skin biopsy may be needed in unusual cases. If no clear cause is obvious, it may be necessary to search for one. Blood tests, an endoscopy, or X-rays may be required to eliminate the possibility of diabetes or cancer as the cause. [6]: 87 On biopsy, hyperkeratosis, epidermal folding, leukocyte infiltration, and melanocyte proliferation may be ...
The disease can cause dangerously low cortisol ... It can also cause hyperpigmentation, or a darkening of the skin that can make people appear bronzed. ... Addison's is rare — but health ...
"Hyperpigmentation just means darkening of the skin," says Dr. Dowling. "So basically, 'hyperpigmentation' is an umbrella term for lots of different conditions that cause hyperpigmentation ...
The disease referred to a chronic progressive adrenal insufficiency, and was described in 1855 by the Englishman Thomas Addison, who gave it his name, Addison's disease. [9] The cardinal signs included asthenia , low blood pressure , anorexia (with weight loss) and melanoderma, with hyperpigmentation of the skin at friction points and of the ...
What it looks like: Rosacea causes redness and thick skin on the face, usually clustered in the center. Easy flushing, a stinging sensation, and small, pus-filled pimples are other common signs of ...
Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. [4] [9] [10] Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, a round red face due to facial plethora, [11] a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals ...
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