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Mupirocin, sold under the brand name Bactroban among others, is a topical antibiotic useful against superficial skin infections such as impetigo or folliculitis. [ 5 ] [ 6 ] [ 7 ] It may also be used to get rid of methicillin-resistant S. aureus (MRSA) when present in the nose without symptoms. [ 6 ]
[1] [2] It contains the three antibiotics neomycin, polymyxin B, and bacitracin. [1] It is for topical use. [3] [4] Possible side effects include itchiness and skin rash, [5] and in rare cases hearing loss. [5] It is relatively broad spectrum, being effective against both Gram-negative and Gram-positive bacteria. [2]
The use of mupirocin ointment can reduce the rate of infections due to nasal carriage of S. aureus. [139] There is limited evidence that nasal decontamination of S. aureus using antibiotics or antiseptics can reduce the rates of surgical site infections.
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It is most commonly used as a topical antibiotic ointment. [2] It is effective against gram-positive bacteria , gram-negative bacteria , and can be used in the treatment of trypanosomiasis . [ 1 ] [ 3 ] [ 4 ] Its use in medicine has become less frequent, as safer and more effective products have become available. [ 5 ]
Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic.In dermatological use, [4] it is spelled polihexanide and sold under various brand names. [5]
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