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Ledipasvir is a drug for the treatment of hepatitis C that was developed by Gilead Sciences. [1] After completing Phase III clinical trials, on February 10, 2014, Gilead filed for U.S. approval of a ledipasvir/sofosbuvir fixed-dose combination tablet for genotype 1 hepatitis C. [2] [3] The ledipasvir/sofosbuvir combination is a direct-acting antiviral agent that interferes with HCV replication ...
It is a fixed-dose combination of ledipasvir and sofosbuvir. [8] Cure rates are 94% to 99% in people infected with hepatitis C virus (HCV) genotype 1. [9] Some evidence also supports use in HCV genotype 3 and 4. [9] It is taken daily by mouth for 8–24 weeks. [8] It is generally well tolerated. [10]
Before 2012, sustained response occurred in about 40–50% of those with HCV genotype 1 who received 48 weeks of treatment. [5] A sustained response was seen in 70–80% of people with HCV genotypes 2 and 3 following 24 weeks of treatment. [5] A sustained response occurs for about 65% of those with genotype 4 after 48 weeks of treatment.
In all cases, after just 12 weeks of treatment, 95 percent of people diagnosed with hepatitis C are cured. How to Prevent Hepatitis C Cured of hepatitis C, however, doesn’t mean immune.
Sofosbuvir is a once-daily oral nucleotide analogue inhibitor for the treatment of chronic hepatitis C virus. Skip to main content. Finance. 24/7 Help. For premium support please call: ...
Elbasvir/grazoprevir, sold under the brand name Zepatier, is a fixed-dose combination for the treatment of hepatitis C, containing elbasvir (an inhibitor of hepatitis C virus's NS5A protein) and grazoprevir (an NS3/4A inhibitor). It is used to treat chronic hepatitis C virus (HCV) genotypes 1 or 4 infection in both treatment-naïve and ...
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An SVR after 24 weeks off therapy of 75% was achieved in the group treated for 48 weeks with four weeks of lead-in therapy with peginterferon alfa-2b plus ribavirin followed by the addition of boceprevir. This represents a near doubling of the rate of SVR compared to standard therapy without boceprevir in this group. [citation needed]
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