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Second, the drug dose the patient received, and if its amount is commensurate with developing CIPN, must be considered. [1] The immunomodulatory drug bortezomib, for example, is more likely to cause neurotoxicity in a cumulative dose of 20 grams. Finally, the characteristics and the duration of a patient's symptoms should be analyzed.
Carboplatin, sold under the brand name Paraplatin among others, is a chemotherapy medication used to treat a number of forms of cancer. [3] This includes ovarian cancer , lung cancer , head and neck cancer , brain cancer , and neuroblastoma . [ 3 ]
Oncologists are already individualizing dosing of some cancer drugs based on exposure. Carboplatin [29]: 4 and busulfan [30] [31] dosing rely upon results from blood tests to calculate the optimal dose for each person. Simple blood tests are also available for dose optimization of methotrexate, [32] 5-FU, paclitaxel, and docetaxel. [33] [34]
For the last couple of months, they’ve been rationing by rounding down doses of carboplatin by 10%, which Gordan said doesn’t diminish the drug’s efficacy. “We have been rounding down for ...
A dose–response curve is a coordinate graph relating the magnitude of a dose (stimulus) to the response of a biological system. A number of effects (or endpoints) can be studied. The applied dose is generally plotted on the X axis and the response is plotted on the Y axis. In some cases, it is the logarithm of the dose that is plotted on the ...
The occurrence of adriamycin-related cardiac toxicity is related to the total lifetime dose of adriamycin, and increases sharply in people who receive a cumulative dose of more than 400 mg/m 2. Almost all patients treated with ABVD receive less than this dose (for 6 cycles of ABVD, the cumulative adriamycin dose is 300 mg/m 2 ); therefore ...
Dose limit – higher doses cause high toxicity and long-term use lead to cumulative neurotoxicity and hematopoietic toxicity. [ 12 ] Neuropathy which is significant side effect can develop at any time in therapy and require an interruption of treatment.
The IC 50 of a drug can be determined by constructing a dose-response curve and examining the effect of different concentrations of antagonist on reversing agonist activity. IC 50 values can be calculated for a given antagonist by determining the concentration needed to inhibit half of the maximum biological response of the agonist. [ 4 ]