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Genetic studies of founder effect have concentrated on discovering ancestral and novel genetic diseases caused by founder effect and, to a lesser degree, on ancestry-related founder effects on populations, races, and ancient migrations, as well other aspects.
The founder population could be the common ancestry of Arabs or the forced localizations caused by artificial countries inside the larger group of ancestry, hence causing Arab specific founder effect mutation disease found only in all Arabic countries, and Arabic country specific mutation diseases caused by increasing Homozygosity (the ...
Schematic illustration of maternal (mtDNA) gene-flow in and out of Beringia, from 25,000 years ago to present. The genetic history of the Indigenous peoples of the Americas is divided into two distinct periods: the initial peopling of the Americas from about 20,000 to 14,000 years ago (20–14 kya), and European contact, after about 500 years ago.
The genetic divergence of R1a (M420) is estimated to have occurred 25,000 [2] years ago, which is the time of the last glacial maximum.A 2014 study by Peter A. Underhill et al., using 16,244 individuals from over 126 populations from across Eurasia, concluded that there was "a compelling case for the Middle East, possibly near present-day Iran, as the geographic origin of hg R1a". [2]
The diseases are not restricted to Finns; they are genetic diseases with far wider distribution in the world, but due to founder effects and genetic isolation they are more common in Finns. Within Finland these diseases are more common in the east and north, consistent with their higher association with ethnic Finns than with ethnic Swedes . [ 2 ]
Because of a founder effect, the ancestors of present-day Ashkenazi Jews may have kept the low-frequency G2019S mutation through the different diasporas, whereas Near Eastern daughter populations lost the mutation. The mutation might then have been "reintroduced by recurrent gene flow from Ashkenazi populations to other Jewish, European, and ...
The rapid expansion of a previously small population has two important effects on the distribution of genetic variation. First, the so-called founder effect occurs when founder populations bring only a subset of the genetic variation from their ancestral population. Second, as founders become more geographically separated, the probability that ...
The founder effect is a special case of a population bottleneck, occurring when a small group in a population splinters off from the original population and forms a new one. The random sample of alleles in the just formed new colony is expected to grossly misrepresent the original population in at least some respects. [44]