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A diagnosis of vitamin B 12 deficiency is determined by blood levels lower than 200 or 250 picograms per ml (148 or 185 picomoles per liter). [3] Some people can have symptoms with their normal levels of the vitamin, or may have low levels despite having no symptoms. [5] Other tests may be done to ensure individuals status. [3]
The vitamin is then transferred to TC2, which serves as the circulating plasma transporter, hereditary defects in the production of TC2 and its receptor may produce functional deficiencies in B 12 and infantile megaloblastic anemia, and abnormal B 12 related biochemistry, even in some cases with normal blood B 12 levels.
Folate deficiency can be secondary to vitamin B 12 deficiency or a defect in homocysteine methyl transferase that leads to a "folate trap" in which is an inactive metabolite that cannot be recovered. [1] Diagnosis is typically confirmed by blood tests, including a complete blood count, and serum folate levels. [1]
Lack of vitamin B12 can cause megaloblastic anemia—a condition characterized by larger than normal red blood cells in a smaller than normal amount. This causes fatigue, paleness in the skin ...
2. Vitamin B12. One of eight B-complex vitamins, vitamin B12 is found naturally in some types of fish, red meat and fortified foods.It plays a key role in central nervous system function, DNA ...
In adults, normal total body folate is between 10 and 30 mg with about half of this amount stored in the liver and the remainder in blood and body tissues. [1] In plasma, the natural folate range is 150 to 450 nM. [15] Folate was discovered between 1931 and 1943. [16] It is on the World Health Organization's List of Essential Medicines. [17]
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