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Folate in the form of folic acid is used to treat anemia caused by folate deficiency. [3] Folic acid is also used as a supplement by women during pregnancy to reduce the risk of neural tube defects (NTDs) in the baby. [3] [10] NTDs include anencephaly and spina bifida, among other defects.
Signs of folate deficiency anemia most of the time are subtle. [4] Anemia (macrocytic, megaloblastic anemia) can be a sign of advanced folate deficiency in adults. [1] Folate deficiency anemia may result in feeling tired, weakness, changes to the color of the skin or hair, open sores on the mouth, shortness of breath, palpitations, lightheadedness, cold hands and feet, headaches, easy bleeding ...
Impaired absorption can also result from blind loop syndrome where an overpopulation of bacteria in the small intestine absorb the vitamin. [126] B 12 deficiency caused by Helicobacter pylori was positively correlated with CagA positivity and gastric inflammatory activity, rather than gastric atrophy.
Just don’t exceed 1,000 micrograms of total daily folate, the NIH says, as high doses can hide or exacerbate B12 deficiency and potentially increase risks of colorectal cancer. Multivitamins (maybe)
Folate acts as a co-enzyme in the form of tetrahydrofolate (THF), which is involved in the transfer of single-carbon units in the metabolism of nucleic acids and amino acids. THF is involved in purine and pyrimidine nucleotide synthesis, so is needed for normal cell division, especially during pregnancy and infancy, which are times of rapid growth.
The proton-coupled folate transporter is a protein that in humans is encoded by the SLC46A1 gene. [ 5 ] [ 6 ] [ 7 ] The major physiological roles of PCFTs are in mediating the intestinal absorption of folate (Vitamin B9), and its delivery to the central nervous system .
Tomatoes are also rich in vitamin C, potassium, folate, and vitamin K, he points out. ... It can also help to pair tomatoes with a healthy fat—like olive oil—to help with nutrient absorption ...
3. Folic Acid. Folic acid is a synthetic form of folate, a B vitamin found naturally in many foods. If you eat lots of dark leafy greens (like broccoli, spinach and asparagus), beans, nuts, seeds ...
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