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Tamoxifen, sold under the brand name Nolvadex among others, is a selective estrogen receptor modulator used to prevent breast cancer in women and men. [13] It is also being studied for other types of cancer. [13] It has been used for Albright syndrome. [14] Tamoxifen is typically taken daily by mouth for five years for breast cancer. [14]
Tamoxifen is a pure antiestrogenic trans-isomer and has differential actions at estrogen target tissues throughout the body. Tamoxifen is selectively antiestrogenic in the breast but estrogen-like in bones and endometrial cancer. [24] Tamoxifen undergo phase I metabolism in the liver by microsomal cytochrome P450 (CYP) enzymes.
Its effectiveness is approximately equivalent to that of antiestrogen therapy with selective estrogen receptor modulators (SERMs) like tamoxifen and aromatase inhibitors like anastrozole. [17] The use of high-dose estrogen therapy in breast cancer has mostly been superseded by antiestrogen therapy due to the improved safety profile of the ...
The U.S. Food and Drug Administration (FDA) has officially announced a ban on red dye No. 3, or erythrosine, from foods and oral medications due to a potential cancer risk. Food manufacturers have ...
Eating Well. Stanley Tucci just shared his favorite 5-minute high-protein lunch: 'It’s genius' News. News. Associated Press. Attorneys for fire victim say utility may have destroyed evidence of ...
A nonsteroidal estrogen is an estrogen with a nonsteroidal chemical structure. [1] The most well-known example is the stilbestrol estrogen diethylstilbestrol (DES). [1] [2] Although nonsteroidal estrogens formerly had an important place in medicine, they have gradually fallen out of favor following the discovery of toxicities associated with high-dose DES starting in the early 1970s, and are ...
Cheap Restaurants in Every State. Diners are always looking for a cheap and delicious bite. To that end, Cheapism compiled this list of well-reviewed and cheap restaurants in all 50 states and ...
The core items are deemed to be the most cost-effective options for key health problems and are usable with little additional health care resources. [4] The complementary items either require additional infrastructure such as specially trained health care providers or diagnostic equipment or have a lower cost–benefit ratio . [ 4 ]
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