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Primodos was a hormone-based pregnancy test, produced by Schering AG, and used in the 1960s and 1970s that consisted of two pills that contained norethisterone (as acetate) and ethinylestradiol. [ 1 ] [ 2 ] It detected pregnancy by inducing menstruation in women who were not pregnant.
Margaret Crane's patent illustration for "Diagnostic Test Device", the first home pregnancy test. Margaret M. Crane (Meg Crane) is an American inventor and graphic designer who created the first at home pregnancy test in 1967 while working at Organon Pharmaceuticals in West Orange, New Jersey. [1]
Immunologic pregnancy tests were introduced in 1960 when Wide and Gemzell presented a test based on in-vitro hemagglutination inhibition. This was a first step away from in-vivo pregnancy testing [ 42 ] [ 43 ] and initiated a series of improvements in pregnancy testing leading to the contemporary at-home testing. [ 43 ]
Gravindex is an agglutination inhibition test performed on a urine sample to detect pregnancy. [1] It is based on double antigen antibody reaction. The test detects the prevention of agglutination of HCG -coated latex particles by HCG present in the urine of pregnant women.
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