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The miR-15 microRNA precursor family is made up of small non-coding RNA genes that regulate gene expression. The family includes the related mir-15a and mir-15b sequences, as well as miR-16-1, miR-16-2, miR-195 and miR-497. These six highly conserved miRNAs are clustered on three separate chromosomes. [1]
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For example, the pre-miRNAs hsa-mir-194-1 and hsa-mir-194-2 lead to an identical mature miRNA (hsa-miR-194) but are from genes located in different genome regions. Species of origin is designated with a three-letter prefix, e.g., hsa-miR-124 is a human ( Homo sapiens ) miRNA and oar-miR-124 is a sheep ( Ovis aries ) miRNA.
MicroRNA-19, or miR-19, is a member of the OncomiR-1 family, and consists of three sub classifications in both humans and mice: mir-19a, mir-19b1 and miR-19b2. miR-19 has been shown to downregulate phosphatase and tensin homolog (PTEN) effectively increasing activity of the cellular survival-promoting signal pathway PI3K-Akt. [11]
U.S. scientists Victor Ambros and Gary Ruvkun won the 2024 Nobel Prize in Medicine on Monday for the discovery of microRNA and its crucial role in how multicellular organisms grow and live. Their ...
When the viral mir-BART5 was depleted using its anti-miRNA, anti-miR-BART5, cell apoptosis was triggered and resulted in disease control, killing the cells that are identified as infected. [21] Another peculiar case of host-viral interaction mediated by a microRNA occurs with the hepatitis C virus (HCV).
n/a Ensembl ENSG00000207713 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 12: 6.96 – 6.96 Mb n/a PubMed search n/a Wikidata View/Edit Human MicroRNA 200c is a microRNA that in humans is encoded by the MIR200C gene. Function MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression ...
Two people are dead after a plane crashed into a building near the Daniel K. Inouye International Airport in Honolulu, according to reports. At around 3:15 p.m. local time on Tuesday, Kamaka Air ...