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Under normal conditions, there are usually less than 5 white blood cells per μL of CSF. In a pleocytic setting, the number of lymphocytes can jump to more than 1,000 cells per μL. Increases in lymphocyte count are often accompanied by an increase in cerebrospinal protein concentrations in addition to pleocytosis of other types of white blood ...
However, elevated blood sugar levels (hyperglycemia) result in elevated CSF glucose levels [3] as the CSF glucose level is proportional to the blood glucose level with glucose being actively transported as well as simply diffusing down the concentration gradient from blood to CSF. In addition, damage to small blood vessels during lumbar ...
A closely related test, CSF total protein is a measurement used to determine the levels of protein in cerebrospinal fluid. [2] [3] It combines the albumin, IgG, and other proteins. It can be useful in distinguishing among causes of Meningitis. It is more likely to be elevated in bacterial meningitis than in viral meningitis.
This pattern distinguishes Guillain–Barré syndrome from other conditions (such as lymphoma and poliomyelitis) in which both the protein and the cell count are elevated. Elevated CSF protein levels are found in approximately 50% of patients in the first 3 days after onset of weakness, which increases to 80% after the first week. [5]
[1]: 793 Glycine concentrations in the CSF of affected patients are typically more markedly elevated than in plasma, leading to a corresponding elevation in the ratio of glycine concentrations in the cerebral spinal fluid to that in the plasma. This ratio can also be slightly elevated in patients receiving valproic acid. [1]: 811
Typically for an OCB analysis, the CSF is concentrated and the serum is diluted. After this dilution/concentration prealbumin appears as higher on CSF. Albumin is typically the dominant band on both fluids. Transferrin is another prominent protein on CSF column because its small molecular size easily increases its filtration in to CSF.
CSF is derived from blood plasma and is largely similar to it, except that CSF is nearly protein-free compared with plasma and has some different electrolyte levels. Due to the way it is produced, CSF has a lower chloride level than plasma, and a higher sodium level. [2] [6] CSF contains approximately 0.59% plasma proteins, or approximately 15 ...
CT or MRI may show cortical atrophy or white matter lesions. CSF examination usually reveals normal pressure, cell count, and total protein content; however, CSF globulin is almost always elevated, constituting up to 20 to 60% of CSF protein. Serum and CSF contain elevated levels of measles virus antibodies.