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Hippocampal sclerosis (HS) or mesial temporal sclerosis (MTS) is a neuropathological condition with severe neuronal cell loss and gliosis in the hippocampus. [1] Neuroimaging tests such as magnetic resonance imaging (MRI) and positron emission tomography (PET) may identify individuals with hippocampal sclerosis. [2]
Mesial temporal sclerosis, pattern of hippocampal neuron cell loss; Mohr–Tranebjærg syndrome, also known as deafness–dystonia syndrome; MTS assay, a biochemical cell assay used in research; Muir–Torre syndrome, a cancer syndrome
Mesial temporal sclerosis is a specific pattern of hippocampal neuronal loss accompanied by hippocampal gliosis and atrophy. [18] Complex partial seizures occur when excessive and synchronous electrical brain activity causes the impaired awareness and responsiveness. [ 19 ]
Hippocampal sclerosis including Ammon's horn sclerosis that is specific to the mesial temporal lobe, is the most common type of such tissue damage. [ 129 ] [ 130 ] It is not yet clear, however, whether the epilepsy is usually caused by hippocampal abnormalities or whether the hippocampus is damaged by cumulative effects of seizures. [ 131 ]
According to one study, prolonged seizures in a rat model of mesial temporal lobe epilepsy have led to the loss of reelin-expressing interneurons and subsequent ectopic chain migration and aberrant integration of newborn dentate granule cells. Without reelin, the chain-migrating neuroblasts failed to detach properly. [174]
Sclerosis (from Ancient Greek σκληρός (sklērós) 'hard') is the stiffening of a tissue or anatomical feature, usually caused by a replacement of the normal organ-specific tissue with connective tissue. The structure may be said to have undergone sclerotic changes or display sclerotic lesions, which refers to the process of sclerosis.
Nearly 2.3 million people are estimated to be living with multiple sclerosis around the world, but when Montel Williams received his official diagnosis back in 1999, not much was known about the ...
Nearly all reports of seizure outcome following these procedures indicate that the best outcome group includes patients with MRI evidence of mesial temporal sclerosis (hippocampal atrophy with increased T-2 signal). The range of seizure-free outcomes for these patients is reported to be between 80% and 90%, which is typically reported as a sub ...