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NovoLog/ insulin aspart injection: Software used: Preview: Conversion program: macOS Version 10.14.4 (Build 18E227) Quartz PDFContext: Encrypted: no: Page size: 612 x 792 pts (letter) Version of PDF format: 1.3
The combination of the fast-acting form and the long-acting form allows the patient to receive fewer injections over the course of the day. [27] NovoLog Mix is marketed to be used with the Novo Nordisk FlexPen. [28] The onset of action is less than 30 minutes, the peak action is reached in 1–4 hours, and the duration is less than 24 hours. [29]
The onset of action of subcutaneous insulin glargine is somewhat slower than NPH human insulin. It is clear solution as there is no zinc in formula. [ 9 ] [ better source needed ] The biosimilar insulin glargine-yfgn (Semglee) was approved for medical use in the United States in July 2021, [ 10 ] and in the European Union in March 2018.
An injector pen consists of a chamber or cartridge of medication, a tip to attach a needle, and a piston or plunger to inject the dose. [4] Some pens, including most insulin pens, include dials to adjust the dose of the injection before each administration. [2]
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The EC 50 of a quantal dose response curve represents the concentration of a compound where 50% of the population exhibit a response, [5] after a specified exposure duration. For clarification, a graded dose response curve shows the graded effect of the drug (y axis) over the dose of the drug (x axis) in one or an average of subjects.
The company makes several drugs under various brand names, including Levemir, Tresiba, NovoLog, Novolin R, NovoSeven, NovoEight, and Victoza. [1] Novo Nordisk employs more than 48,000 people globally, and markets its products in 168 countries. [7]
Most insulins form hexamers, which delay entry into the blood in active form; these analog insulins do not but have normal insulin activity. Newer varieties are now pending regulatory approval in the US which are designed to work rapidly, but retain the same genetic structure as regular human insulin .