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ATtRACt database: a database of RNA binding proteins and associated motifs. SplicedAid-F: a database of hand -cureted human RNA binding proteins database. RsiteDB: RNA binding site database; SPOT-Seq-RNA: Template-based prediction of RNA binding proteins and their complex structures. SPOT-Struct-RNA: RNA binding proteins prediction from 3D ...
Recent discoveries implicating RNA in the pathogenesis of several forms of cancer and neuromuscular diseases have created a paradigm shift in drug discovery.This work combined with advances in structural characterization techniques such as NMR spectroscopy, X-ray crystallography, Cryogenic electron microscopy [1] together with computational modeling, [2] has pushed forward the realization that ...
The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs in the N-terminal domain which are pivotal for RNA specificity and binding. The protein also has a glycine rich arginine-glycine-glycine (RGG) region called the RGG box which enables protein and RNA binding. It affects many critical genes that are ...
The hnRNP proteins have distinct nucleic acid binding properties; The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs, making it very similar to the family member HNRPF in that regard. This gene is thought to be potentially involved in hereditary lymphedema type I phenotype. [7]
The perinucleolar compartment was first discovered due to characterizing the polypyrimidine tract-binding protein (PTB), which is an RNA binding protein involved with pre-mRNA splicing, stability, and regulating translation. [7] The PTB and other binding proteins are localized in the PNC to primarily process RNA polymerase II.
The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [ 7 ]
Since most mature RNA is exported from the nucleus relatively quickly, most RNA-binding protein in the nucleus exist as heterogeneous ribonucleoprotein particles. After splicing has occurred, the proteins remain bound to spliced introns and target them for degradation.
100043257 Ensembl ENSG00000102317 n/a UniProt P98179 n/a RefSeq (mRNA) NM_001017430 NM_001017431 NM_006743 XM_036156140 RefSeq (protein) NP_006734 n/a Location (UCSC) Chr X: 48.57 – 48.58 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Putative RNA-binding protein 3 is a protein that in humans is encoded by the RBM3 gene. Function This gene is a member of the glycine -rich RNA ...