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Excitation-contraction coupling in myocardium relies on sarcolemma depolarization and subsequent Ca 2+ entry to trigger Ca 2+ release from the sarcoplasmic reticulum. When an action potential depolarizes the cell membrane, voltage-gated Ca 2+ channels (e.g., L-type calcium channels) are activated.
Traditional methods of delivering therapeutics to the body experience challenges in achieving and maintaining maximum therapeutic effect while avoiding the effects of drug toxicity. Many drugs that are delivered orally or parenterally do not include mechanisms for sustained release, and as a result they require higher and more frequent dosing ...
Leidenfrost effect (physical phenomena) Lenard effect (physics) Lense–Thirring effect (effects of gravitation) (tests of general relativity) Leveling effect (chemistry) Levels-of-processing effect (educational psychology) (psychology) (psychological theories) Liquid Sky (effect) (lasers) (stage lighting) Little–Parks effect (condensed ...
Endothelial dysfunction induces coronary vasoconstriction. This is caused by catecholamine release and by infections. Severe infections lead to increase myocardial metabolic demands and hypoxia. When neuronal tissue is deprived of adequate oxygen, the haemodynamic response has less of an effect at active neuronal tissue.
The current ratio divides current assets by current liabilities. For instance, Alphabet’s Q2 2024 balance sheet had $162.0 billion in current assets compared to $77.9 billion in current liabilities.
Physiological relevance is a critical factor in biomedical research because it helps to bridge the gap between basic science and clinical application. Researchers aim to design studies that not only yield statistically significant results but also have direct implications for understanding human health and disease. [ 1 ]
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The largest contribution to the allostatic load is the effect of stress on the brain. Allostasis is the system which helps to achieve homeostasis. [18] Homeostasis is the regulation of physiological processes, whereby systems in the body respond to the state of the body and to the external environment. [18]