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A favorable outcome is more likely if a kidney transplant is complemented by a liver transplant, given the disease originates in the liver. [citation needed] Secondary hyperoxaluria is much more common than primary hyperoxaluria, and should be treated by limiting dietary oxalate and providing calcium supplementation. [citation needed]
Some of the oxalate in urine is produced by the body. Calcium and oxalate in the diet play a part but are not the only factors that affect the formation of calcium oxalate stones. Dietary oxalate is found in many vegetables, fruits, and nuts. Calcium from bone may also play a role in kidney stone formation. Calcium phosphate: 10–20%
Oxalic acid binds with calcium to form calcium oxalate crystals which may deposit and cause damage to many areas of the body including the brain, heart, kidneys, and lungs. [7] The most significant effect is accumulation of calcium oxalate crystals in the kidneys which causes kidney damage leading to oliguric or anuric acute kidney failure. [7]
In people who have had multiple episodes of calcium oxalate kidney stones, chlortalidone lowers the risk of having another episode of kidney stones. [30] Chlortalidone is more effective than hydrochlorothiazide for lowering urine calcium levels and is therefore probably more effective. [31]
A single kidney stone in children or recurrent stones in adults is often the first warning sign of primary hyperoxaluria. Other symptoms range from recurrent urinary tract infections , severe abdominal pain or pain in the side, blood in the urine , to chronic kidney disease and kidney failure . [ 1 ]
Cultural groups with diets that depend highly on fruits and vegetables high in calcium oxalate, such as those in Micronesia, reduce the level of it by boiling and cooking them. [4] [5] They are a constituent in 76% of human kidney stones. [6] Calcium oxalate is also found in beerstone, a scale that forms on containers used in breweries.
In kidney stones, calcium oxalate is the most common mineral type (see nephrolithiasis). Uric acid is the second most common mineral type, but an in vitro study showed uric acid stones and crystals can promote the formation of calcium oxalate stones. [1]
Alkaline citrates are used to prevent recurrent calcium stone formation. [13] [14] [15] [5] This is one of the major types of kidney stones. [16] [17] The citrate salts can increase urine citrate, which binds with urine calcium, reduces supersaturation of calcium salts, and inhibits crystal formation. [18] [8] This helps prevent kidney stones ...
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