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Like nearly all other forms of NSCLC, the prognosis of basaloid squamous cell carcinoma is quite poor. [ 16 ] Although case numbers tend to be rather small, and the published studies statistically underpowered , much (but not all) [ 15 ] evidence suggests that basaloid squamous cell lung carcinomas may have a somewhat worse prognosis than ...
Squamous-cell carcinoma (SCC), also known as epidermoid carcinoma, comprises a number of different types of cancer that begin in squamous cells. [1] These cells form on the surface of the skin, on the lining of hollow organs in the body, and on the lining of the respiratory and digestive tracts .
The 2015 WHO classification of lung tumors [8] divided squamous cell lung carcinomas into 3 categories: keratinizing, non-keratinizing and basaloid. Keratinizing SCC harbor features of keratinization; non-keratinizing SCC lack such features but show other squamous markers, such as p40 and p63; finally, basaloid SCC is a rare subset of poorly ...
Comparison H&E stain (left) with BerEP4 immunohistochemistry staining (right) on a pathological section having BCC with squamous cell metaplasia. Only BCC cells are stained with BerEP4. [ 1 ] Comparison H&E stain (left) with BerEP4 immunohistochemistry staining (right) on superficial BCC pathological sections mimicking Bowen’s Disease. [ 1 ]
Basaloid forms of lung carcinoma were first described in the peer-reviewed medical literature by Dr. Elisabeth Brambilla and her colleagues in 1992. [11] They were first recognized as distinct clinicopathological variants of both squamous cell and large cell lung cancers in 1999, within the third revision of the World Health Organization lung tumor typing and classification scheme.
Squamous-cell carcinoma of the skin is generally distinguishable by for example relatively more cytoplasm, horn cyst formation and absence of palisading and cleft formations. Yet, a high prevalence means a relatively high incidence of borderline cases, such as basal-cell carcinoma with squamous cell metaplasia (H&E stain at left in image).
M8083/3 Basaloid squamous cell carcinoma; M8084/3 Squamous cell carcinoma, clear cell type; 809–811 Basal cell Neoplasms. M8090/1 Basal cell tumor (C44._)
Squamous cell carcinoma; Squamous cell skin cancer; Skin adnexal tumors (e.g. sebaceous carcinoma) Melanoma; Merkel cell carcinoma; Keratoacanthoma; Sarcomas of primary cutaneous origin (e.g. dermatofibrosarcoma protuberans) Lymphomas of primary cutaneous origin (e.g. mycosis fungoides)