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Thyroid hormone uptake (T uptake or T 3 uptake) is a measure of the unbound thyroxine binding globulins in the blood, that is, the TBG that is unsaturated with thyroid hormone. [2] Unsaturated TBG increases with decreased levels of thyroid hormones. It is not directly related to triiodothyronine, despite the name T 3 uptake. [2] Reference ranges:
Thyroxine-binding globulin (TBG) is a globulin protein encoded by the SERPINA7 gene in humans. TBG binds thyroid hormones in circulation . It is one of three transport proteins (along with transthyretin and serum albumin ) responsible for carrying the thyroid hormones thyroxine (T 4 ) and triiodothyronine (T 3 ) in the bloodstream.
More specifically, optimal levels are generally close to a central tendency of the values found in the population. However, usual and optimal levels may differ substantially, most notably among vitamins and blood lipids, so these tables give limits on both standard and optimal (or target) ranges.
Thyroglobulin (Tg) is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Tg is secreted and accumulated at hundreds of grams per litre in the extracellular compartment of the thyroid follicles, accounting for approximately half of the protein content of the thyroid gland. [5]
Fasting in healthy, euthyroid people causes reduced T3 and elevated rT3, although TSH is usually unchanged. [3] [5] [10] Even moderate weight loss can lower T3. [2] This may be primarily via reduced levels of leptin (the satisfaction hormone). Low leptin levels can downregulate hypothalamic TRH neurons and cause a reduction in TSH.
5-60 × 10 −12: Thyroxine (FT4) free 8-24 × 10 −12: total 4-12 × 10 −8: Thyroxine-binding prealbumin: 2.8-3.5 × 10 −4: Thyroxine-binding globulin: 1.0-3.4 × 10 −7: Tin: 0-4 × 10 −7: 0-1 × 10 −7: alpha-Tocopherol (Vitamin E) 5-20 × 10 −6: Transcortin: male 1.5-2 × 10 −5: female 1.6-2.5 × 10 −5: Transferrin: newborn 1 ...
Testosterone Levels By Age. Around the age of 35, men's testosterone levels begin to decline more rapidly. Average Testosterone Levels By Age. The average male who reaches 70 years old will have ...
The reduced level of transthyretin in the CSF may indicate a lower thyroxine transport in brains of patients with schizophrenia. Transthyretin is known to contain a Gla domain , and thus be dependent for production on post-translational modification requiring vitamin K , but the potential link between vitamin k status and thyroid function has ...