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  2. Sickle cell disease - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell_disease

    Sickle cell disease (SCD), also simply called sickle cell, is a group of hemoglobin-related blood disorders that are typically inherited. [2] The most common type is known as sickle cell anemia. [2] Sickle cell anemia results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. [2]

  3. Sickle cell trait - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell_trait

    The sickle cell trait provides a survival advantage against malaria fatality over people with normal hemoglobin in regions where malaria is endemic. The trait is known to cause significantly fewer deaths due to malaria, especially when Plasmodium falciparum is the causative organism.

  4. Mendelian traits in humans - Wikipedia

    en.wikipedia.org/wiki/Mendelian_traits_in_humans

    Autosomal dominant A 50/50 chance of inheritance. Sickle-cell disease is inherited in the autosomal recessive pattern. When both parents have sickle-cell trait (carrier), a child has a 25% chance of sickle-cell disease (red icon), 25% do not carry any sickle-cell alleles (blue icon), and 50% have the heterozygous (carrier) condition. [1]

  5. Dr. Tartania Brown on importance of believing patients living ...

    www.aol.com/dr-tartania-brown-importance...

    “People living with sickle cell are not trying to game the system. They’re really just asking for help and support The post Dr. Tartania Brown on importance of believing patients living with ...

  6. NHS to offer 'groundbreaking' sickle cell gene therapy - AOL

    www.aol.com/news/nhs-offer-groundbreaking-sickle...

    A gene-editing therapy for sickle cell disease, with a price tag of £1.65m, is to be offered to patients on the NHS in England. About 50 people a year with the inherited blood disorder are likely ...

  7. Hemoglobin A2 - Wikipedia

    en.wikipedia.org/wiki/Hemoglobin_A2

    HbA2 is also important for diagnosing sickle cell disease, which is one of the most prevalent genetic conditions. Sickle cell disease exhibits characteristics of either homozygous hemoglobin S, also known as Hb S, or Hb S paired with another hemoglobin variant.

  8. Koller's sickle - Wikipedia

    en.wikipedia.org/wiki/Koller's_sickle

    Avian epiblast differentiation. Koller's sickle composes the blue-colored area in image D, associated with the green-colored area opaca and the red-colored area pellucida. [1] In avian gastrulation, Koller's sickle is a local thickening of cells at the posterior edge of the upper layer of the area pellucida called the epiblast. Koller's sickle ...

  9. Heterozygote advantage - Wikipedia

    en.wikipedia.org/wiki/Heterozygote_advantage

    The pathogen that causes the disease spends part of its cycle in the red blood cells and triggers an abnormal drop in oxygen levels in the cell. In carriers, this drop is sufficient to trigger the full sickle-cell reaction, which leads to infected cells being rapidly removed from circulation and strongly limiting the infection's progress.

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