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Although meropenem is not approved for intramuscular or subcutaneous routes of administration in humans, there were studies that evaluated the drug bioavailability in cats and reported bioavailability of 99.69% for intramuscular route and 96.52 % for subcutaneous route of administration; these studies also compared elimination half-lives for ...
Meropenem works by blocking the construction of the bacterial cell wall while vaborbactam blocks the breakdown of meropenem by some beta-lactamases. [ 4 ] The combination was approved for medical use in the United States in 2017, [ 6 ] in the European Union in 2018, [ 4 ] [ 3 ] and in Canada in December 2024. [ 1 ]
The β-lactam core structures. (A) A penam.(B) A carbapenam.(C) An oxapenam.(D) A penem.(E) A carbapenem.(F) A monobactam.(G) A cephem.(H) A carbacephem.(I) An oxacephem. This is a list of common β-lactam antibiotics—both administered drugs and those not in clinical use—organized by structural class.
Meropenem is somewhat less potent than imipenem against gram-positive pathogens, and somewhat more potent against gram-negative infections. Unlike imipenem, which produced an unacceptable rate of seizures in a phase 2 trial, meropenem is effective for the treatment of bacterial meningitis. [ 24 ]
Meropenem, an antibiotic initially marketed under the trade name Merrem Blasius Merrem (1761–1824), German naturalist, zoologist, ornithologist, mathematician, and herpetologist Topics referred to by the same term
Marbofloxacin can be used both orally and topically. It is particularly used for infections of the skin, respiratory system and mammary glands in dogs and cats, as well as with urinary tract infections. For dogs, a dose ranges from 2.75 - 5.5 mg/kg once a day.
A comparison of 3 insecticides (selamectin, fipronil, imidacloprid) showed that selamectin reduced larval cat fleas ≥93.5% after 24 h at doses of ≥0.3 μg. In contrast, at 24 h neither fipronil nor imidacloprid reached 90% reduction, even at the highest doses tested (0.5 μg for fipronil and 5.0 μg for imidacloprid).
A basic litter box and scoop. A litter box, also known as a sandbox, cat box, litter tray, cat pan, potty, pot, or litter pan, is an indoor feces and urine collection box for cats, as well as rabbits, ferrets, miniature pigs, small dogs, and other pets that instinctively or through training will make use of such a repository.
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