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The glomerulus (pl.: glomeruli) is a network of small blood vessels (capillaries) known as a tuft, located at the beginning of a nephron in the kidney. Each of the two kidneys contains about one million nephrons. The tuft is structurally supported by the mesangium (the space between the blood vessels), composed of intraglomerular mesangial cells.
The nephron is the minute or microscopic structural and functional unit of the kidney. It is composed of a renal corpuscle and a renal tubule. The renal corpuscle consists of a tuft of capillaries called a glomerulus and a cup-shaped structure called Bowman's capsule. The renal tubule extends from the capsule.
Diagram of the circulation related to a single glomerulus, associated tubule, and collecting system The renal corpuscle in the cortex (outer layer) of the kidney. At the top, the renal corpuscle containing the glomerulus. The filtered blood exits into the renal tubule as filtrate, at right. At left, blood flows from the afferent arteriole (red ...
Kidney stones (nephrolithiasis) are a relatively common and particularly painful disorder. A chronic condition can result in scars to the kidneys. The removal of kidney stones involves ultrasound treatment to break up the stones into smaller pieces, which are then passed through the urinary tract. One common symptom of kidney stones is a sharp ...
Each nephron is located in both the cortex and the medulla. The most proximal part of the nephron is glomerulus, which is located in the cortex. [28] The nephrons of the mammalian kidneys have loops of Henle, which are the most efficient way to reabsorb water and produce concentrated urine to conserve water in the body. [12]
The glomerular basement membrane of the kidney is the basal lamina layer of the glomerulus.The glomerular endothelial cells, the glomerular basement membrane, and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that forms in Bowman's capsule. [1]
Diagram showing Bowman's capsule as part of the renal corpuscle. The process of filtration of the blood in the Bowman's capsule is ultrafiltration, and the normal rate of filtration is 125 ml/min, equivalent to 80 times the daily blood volume. [citation needed] It is a major site for blood filtration (including glomerulus)
Each nephron begins in a renal corpuscle, which is composed of a glomerulus enclosed in a Bowman's capsule. Cells, proteins, and other large molecules are filtered out of the glomerulus by a process of ultrafiltration , leaving an ultrafiltrate that resembles plasma (except that the ultrafiltrate has negligible plasma proteins ) to enter Bowman ...