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Hyperoxaluria is an excessive urinary excretion of oxalate. Individuals with hyperoxaluria often have calcium oxalate kidney stones. It is sometimes called Bird's disease, after Golding Bird, who first described the condition.
After the development of kidney failure patients may get deposits of oxalate in the bones, joints and bone marrow. Severe cases may develop haematological problems such as anaemia and thrombocytopaenia. The deposition of oxalate in the body is sometimes called "oxalosis" to be distinguished from "oxaluria" which refers to oxalate in the urine.
Oxalate also forms coordination compounds where it is sometimes abbreviated as ox. It is commonly encountered as a bidentate ligand. When the oxalate chelates to a single metal center, it always adopts the planar conformation. As a bidentate ligand, it forms a 5-membered MC 2 O 2 ring. An illustrative complex is potassium ferrioxalate, K 3 [Fe ...
Because the test pad reaction is dependent on pH, false positive results can occur if the urine is highly alkaline. [60] [62] Conventional test strips are not sensitive enough to reliably detect microalbuminuria, a condition in which urine albumin levels are slightly elevated, [64] although dipsticks specialized for this measurement exist. [62]
The approval for Novo's therapy is based on studies in which the drug reduced the levels of 24 hour-urinary oxalate excretion measured against a pre-decided baseline value and when compared to ...
The reduced function of the enzyme causes a build-up of glyoxylate in the liver, and in turn causes an increase in oxalate levels in urine. [ 9 ] The reduced enzyme function can be caused by a rare inherited autosomal recessive [ 10 ] disorder known as primary hyperoxaluria type II (PH2).
Some of the oxalate in urine is produced by the body. Calcium and oxalate in the diet play a part but are not the only factors that affect the formation of calcium oxalate stones. Dietary oxalate is found in many vegetables, fruits, and nuts. Calcium from bone may also play a role in kidney stone formation. Calcium phosphate: 10–20%
In fact, “normal” levels of serotonin are not only important for maintaining a stable mood, but also for regulating appetite and our ability to sleep.