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Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC 2.7.3.2) expressed by various tissues and cell types. CK catalyses the conversion of creatine and uses adenosine triphosphate (ATP) to create phosphocreatine (PCr) and adenosine diphosphate (ADP).
Isolated hyperCKemia is a benign [1] genetic disorder which is characterized by high levels of creatine kinase (an enzyme) in the blood, usually, levels of CK in the blood of people with this disorder are 3 to 10 times higher than average.
Proper treatment of SAAM often results in full recovery. [3] Recovery can occur even with persistently elevated creatine kinase (CK) levels. [3] Conversely, some people with SAAM do not regain full muscle strength despite the normalization of their CK levels. [3]
Elevated creatine kinase levels Dry, thinning skin and decreased production of sebum (an oily substance that products your skin) Melasma (a skin condition that involves patches of dark, discolored ...
Blood tests show a creatine kinase activity greater than 1000 U/L, with severe disease being above 5000–15 000 U/L. [5] The mainstay of treatment is large quantities of intravenous fluids. [3] Other treatments may include dialysis or hemofiltration in more severe cases.
Malignant hyperthermia is diagnosed on clinical grounds, but various laboratory investigations may prove confirmatory. These include a raised creatine kinase level, elevated potassium, increased phosphate (leading to decreased calcium) and—if determined—raised myoglobin; this is the result of damage to muscle cells.
A low dosage treatment with creatine showed a significant improvement of muscle problems compared to placebo in a small clinical study, while other studies have shown minimal subjective benefit. [61] [62] High-dosage treatment of creatine has been shown to worsen symptoms of myalgia (muscle pain). [62]
Methods for identifying myolysis after such a snakebite can include testing for creatine kinase levels, which may be elevated, or evaluating myoglobin levels. [10] Treatment with antivenom theoretically has little effect once myolysis has set in; however, even late antivenom treatment may still reduce the severity of injury. Since snake ...